Antibiotics: MOA Flashcards Preview

USMLE Step 1 > Antibiotics: MOA > Flashcards

Flashcards in Antibiotics: MOA Deck (10)
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1

Fluoroquinolones: MOA

  • bactericidal
  • inhibit DNA topoisomerase activity

2

Fluoroquinolones: adverse effects

  • GI upset
  • damage to cartilage @ children
  • tendinitis/tendon rupture in adults
  • mild
    • H/A
    • dizziness
    • rash

3

Aminoglycosides: MOA

  • bactericidal
  • block bacterial protein synthesis through inhibition of 30S ribosomal unit

4

Aminoglycosides: adverse effects

  • nephrotoxicity
  • ototoxicity

5

Macrolides: MOA

  • bacteriostatic
  • blocks protein syntehesis at 50S ribosomal unti

6

Macrolides: adverse effects

  • GI discomfort
  • acute cholestatic hepatitis
  • eosinophilia
  • skin rashes
  • more severe
    • pseudomembranous colitis
    • ventricular arrhythmias

7

Tetracyclines: MOA

  • bacteriostatic agents
  • block protein synthesis by actin at 30S ribosomal subunit

8

Tetracyclines: adverse effects

  • GI distress
  • tooth discoloration
  • inhibition of bone growth @ children
  • photosensitivity rxns
  • more severe
    • bacterial superinfection
    • hepatotoxicity

9

Trimethoprim-sulfamethoxazole: MOA

  • trimethoprim-sulfamethoxazole
    • MOA = inhibitis bacterial folate synthesis via inhibition:
    • dihydropteroate synthetase (trimetho) and dihydrofolate reductase (sulfa)

10

Penicillins: MOA

  • bactericidal
  • inhibition of cell wall synthesis via inhibition of cross-linking of peptidoglycan

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