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Flashcards in UWorld_1.16 Deck (12)
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1

Rheumatoid factor?

IgM antibody specific for Fc portion of IgG

2

Mechanism of RA

  • Anti-IgG (IgM) Abs bind IgG ==> immune complex formation
  • immune complexes ==> deposition @ synovium of joints
  • ==> phalangeal joint deformities + deposition @ elbows and lumbosacral ares

3

Thiamine (Vit B1) deficiency ==>

  • Wet beriberi ==> neuropathy + cardiac involvement usually ==> CHF
  • Dry beriberi ==> symmetrical peripheral neuropathy @ distal extremities
  • Wernicke-Korsacoff ==> confusion, encephalopathy @ alcoholics

4

What causes naseau following chemo?

  • trigger of chemoreceptor trigger zone (CTZ)
  • location = dorsal medulla @ just below level of 4th ventricle in region called "area postrema"

5

Fxn/stimulus of ventromedial hypothalamic nucleus

  • mediates satiety
    • destruction ==> hyperphagia
  • stimulated by leptin

6

Fxn/stimulus of lateral hypothalamic nucleus

  • mediates hunger
    • destruction ==> anorexia
  • inhibited by leptin

7

Fxn of anterior hypothalamic nucleus

  • mediates heat dissipation via parasympathetics
    • destruction ==> hyperthermia

8

Fxn of posterior hypothalamic nucleus

  • mediates heat conservation via sympathetics
    • destruction ==> hypothermia

9

Fxn of arcuate hypothalamic nucleus

  • secretion of hormones:
    • dopamine (inhibits prolactin)
    • GHRH
    • GnRH

10

Fxn of paraventricular hypothalamic nucleus

  • secretion of hormones:
    • ADH
    • CRH
    • Oxytocin
    • thyrotropin-releasing hormone

11

Fxn of supraoptic hypothalamic nucleus

  • secretion of hormones:
    • oxytocin
    • ADH

12

Fxn of suprachiasmatic hypothalamic nucleus

  • circadian rhythm
  • pineal gland fxn

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