Rx_Random Set #2 Flashcards Preview

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Flashcards in Rx_Random Set #2 Deck (30)
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1

Major nutritional deficiency/syndromes in CF?

  • pancreatic insuffiency ==> deficiencies in fat-soluble vitamins (A, K, E, D)
  • A ==> night blind/dry skin
  • K ==> coag problems
  • E ==> RBC dysfxn
  • D ==> Rickett's (children), osteomalacia (adults) 

2

LSD use presentation

  • hallucinations, anxiety or depression, delusions
  • nausea, weakness, paresthesias
  • dilated pupils
  • few observable behavioral changes

3

Sx of phechomocytoma + associations

  • sx = sweating, tachycardia, HTN
  • associatiated w/heritable MEN syndrome
    • MEN-2A
    • MEN-2B

4

MEN-1 Syndrome association

  • "3 Ps"
  • Pancreas
  • Pituitary
  • Parathyroid neoplasms

5

MEN-2 syndrome associations

  • MEN-2A = "2 Ps"
    • Pheochromocytoma
    • Parathyroid cancer
    • medullary thyroid cancer
  • MEN-2B = "1 P"
    • Pheochromocytoma
    • medullary thyroid cancer
    • mucosal neoplasms

6

Specificty definition/calculation

  • specificty = how well test identifies those who are truly non-diseased
    • important in ruling out illness
  • specificity = TN/(TN+FP)

7

Sensitivity definition/calculation

  • sensitivity = probablity of detecting disease when it is present
  • sensitivity = TP/(TP + FN)

8

Horner's syndrome characteristics

  • ptosis
  • miosis
  • anhidrosis

9

Smoker/other lung cancer risk + shoulder pain + hoarseness + Horner's syndrome ==> what tumor type & location

  • squamous cell carcinoma (if smoker) @ apex of ipsilateral lung to neuro deficitis
  • aka "Pancoast's tumor" or "superior sulcus tumor"

10

Recurrent viral infections indicate...

T-lymphocyte dysfxn

11

Helper T cell cytokine deficiency ==> T lymphocyte dysfxn

IL-2

12

Cause/characteristics of fifth disease

  • fifth disease = "erythema infectiosum"
  • caused by Parvovirus B19
  • typically effects children 5-10yo
  • ==> erythematous rash on both cheeks

13

Common drug used in treatment of large B-lymphocyte lymphoma

Methotrexate

14

Methotrexate MOA/use

  • blocks dihydrofolate reductase ==> decreased deoxythymidine monophosphate & decreased DNA and protein synthesis in rapidly dividing cells
  • used to treat B-lymphocyte lymphoma

15

Acute poststreptococcal glomerulonephritis histologic appearance

  • subepithelial deposition of antigen-antibody complexes ==>
  • "lumpy-bumpy" pattern on light microscopy

16

Dx + associated sx? Patient cannot dorsiflex wrist

  • = "wrist drop" ==> indicates radial nerve injury
  • "radial nerve innervates the BEST"
    • Brachioradialis
    • Extensor of wrist/fingers
    • Supinator
    • Triceps

17

Histological appearance of osteoarthiritis @ joint space

  • degeneration of articular cartilage
  • disloged peices of cartilage and subchondral bone

18

Lab values in metabolic alkalosis

  • elevated pH
  • elevated CO2
  • elevated HCO3-

19

Diuretics that can cause metabolic alkalosis

  • hydrochlorothiazide
  • furosemide

20

Common complications in Trisomy 18

  • flexed fingers w/overriding digits
  • prominent occiput
  • congenital heart anomalies

21

Fxn of C5 - C8

complement compoenents involved in membrane attack complex

22

Deficiency of C5-C8 ==>

  • increased susceptibility to gram-negative bacteria
  • e.g. Neisseria meningitidis
    • pyrexia
    • petechial rash
    • blood culture findings

23

Common muscle injury during vaginal delivery

perineal body & external anal sphincter ==> fecal incontinence

24

characteristics of alpha1-antitrypsin deficiency

  • AAT = enzyme normally produced @ liver that destroys elastase produced in lung parenychema 
  • misfolded protease inhibitor ==> overactivity of elastase ==>
  • ephysema
  • cirrhosis

25

Histologic consequences of alpha-antitrypsin deficiency @ hepatocytes

PAS-positive globules

26

Anti-phospholipid syndrome in SLE patients ==>

  • prolonged partial thromboplastin time (PTT)
    • not correctable w/ mixing 1:1 w/fresh-frozen plasma
    • "falsely-elevated"
  • actually predisposes to clot formation
    • DVTs
    • placental clots ==> recurrent fetal loss

27

Main types of renal stones + typical imaging

  • calcium = radiopaque on xray
  • uric acid = radiolucent; seen on CT
  • struvite = xray
  • cystine =xray

28

Syphilis presentation + tx

  • presentation
    • painless chancre in vaginal area
    • positive venereal disease research laboratory test + positive FTA-Abs ==> active infection
  • treatment
    • Penicilin G
    • administered IM

29

Innervation/fxn/location of sweat glands

  • eccrine
    • fxn = thermoregulation; watery solution produced
    • location = throughout skin, most @ palms/soles
    • innervation = sympathetic
  • apocrine
    • fxn = produces oily, viscid solution
    • location = axillae, groin
    • innervation = catecholamines

30

Pharmacologic management of status epilepticus

  • IV diazepam
  • IV phenytoin
  • IV phenobarbitol (if resistant status epilepticus)

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