UWorld_3.25 Flashcards Preview

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Flashcards in UWorld_3.25 Deck (17)
1

Cells that secrete secretin

-S eneteroendocrine cells of duodenum -in response to intraluminal activity -HCL most potent stimulus

2

Components of Hib vaccine

-polysacc capsule particle attached to diptheria toxoid

3

carrier proteins for bacterial capsule polysacc in vaccines

-n. menigitis protein complex -tetanus toxoid -diptheria toxoid

4

Common cardinal veins ==>

==> sinus venousus ==> SVC + systemic veins

5

Erythrocyte glycolysis

-no mitochondria = no oxidative phosphorylation ==> glycolysis as sole method for generating ATP

6

Purpose: bisphosphoglycerate mutase

- converts 1,3-bisphosphoglycerate ==> 2,3-BPG -[2,3-BPG phosphatase can take 2,3-BPG ==> 3-phosphoglycerate] -2,3-BPG regulates O2 binding ==> decreased O2 binding in low O2 settings to increase delivery to tissue

7

Cytokines ==> systemic inflammation

-IL-1, IL-6, TNF-alpha ==> acute phase proteins (e.g. fibrinogen) -APP ==> elevated ESR = nonspecific marker of inflammation

8

Exotoxins that ribosylate EF2 in humans

-Diphtheria toxin -Pseudomonas toxin A

9

Acetozolamide: MOA, use

-MOA: inhibits CA @ proximal tubule ==> excretion of HCO3- + sodium ==> diuresis + alkaline urine + metabolic acidosis -use: open & close-angle glaucoma, others

10

Acute onset dysuria + hematuria in child that self-resovles ==> dx?

-acute hemorrhagic cystitis -common cause: adenovirus (nonenv, icosahedral, linear, non-segmented dsDNA)

11

Homocystinuria presentation and tx

-inborn error of methionine metabolism due to deficiency of cystathione synthase (which uses Vit B6 as cofactor) -Sx: lens dislocation, intellectual disability, marfanoid habitus, risk for thromboembolic events -tx: supplementation of pyroxidine (B6)

12

DRESS syndrome

-Drug Rxn with Eosinophilia & Systemic Sx -2-8 weeks after starting new medication -esp. anticonvulsants, antibiotics, allopurinol, sulfonamides -fever, general lymph, facial swell, eosino, skin rash, organ dysfxn

13

Drug-induced lupus

-hydralazine (HTN drug, arteriolar vasodilator via K channel binding) -procainamide -isoniazid

14

opioid drug that can produce w/drawal in someone on morphine

pentacozine

15

Crohn's: inflam + granulomas?

-transmural inflammation; skip lesions -non-cas. granulomas present

16

Mucicarmine stain used to detect ...?

cryptoccoccus neoformans = red on mucicarmine

17

Phrenic n. roots

C3-C5

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