Rx_3.2 (HemOnc) Flashcards Preview

USMLE Step 1 > Rx_3.2 (HemOnc) > Flashcards

Flashcards in Rx_3.2 (HemOnc) Deck (16)
Loading flashcards...
1

Henoch-Schonlein purpura presentation

  • more common in boys
  • sx
    • palpable prurititc lesions on buttocks and legs
    • arthralgiase
    • fever 
    • malaise
    • episodic abdominal pain
  • ==> acute renal failure w/proteinuria and hematuria
  • glomeruli = IgA + C3 at the mesangium
    • normal serum C3

2

Granular pattern on immunofloursence ==> 

  • PSGN
  • subepithelial IgG and C3

3

Adverse effects of asprisin

  • tinnitus
  • N/V
  • GI irritation
  • ulcer

4

Zafirlukast: MOA

  • blocks leukotriene receptors ==> blocking of mediators of bronchoconstriction in asthma

5

Zileuton: MOA

  • inhibits 5-lipooxygenase pathway ==> prevents conversion of arachidonic acid to leukotriens

6

Streptokinase: MOA

  • activates conversion of plasminogen ==> plasmin ==> breakdown of clots

7

Characteristics of staphylococcal toxic shock syndrome

  • caused by massive cytokine release in response to exotoxin
  • ==> fever + hypotension + dermatologic presentation + multi-organ system involvement, e.g.:
    • GI
    • myalgia
    • renal
    • hepatic
    • hemat
    • CNS
  • acute derm presentation = macular rash @ infection site + palms/soles
  • derm 2 weeks after onset = palmar/plantar desquamation

8

Anaplasia definition

  • irreversible change in which there is a reversion of differentiation ("dedifferentiation")
  • characteristic of aggressive malignant neoplasm

9

Antidote for bleeding due to tPA

  • aminocaproic acid ==I conversion of plasminogen to plasmin

10

Tx for hemophilia A

  • recombinant factor VIII

11

Stop codons

  • UGA
  • UAA
  • UAG

12

Insertion mutation vs. Frameshift mutation

  • frameshift = nucleotide base deletion/insertion that alters reading frame
  • insertion mutation = chromosomal abnormalityDNA segment from one chromosome is inserted into anon-homologous chromosome, maintaining the appropriate reading frame

13

Drugs that irreversibly bock adenosine diphosphate receptors

  • clopidogrel
  • ticlopidine
  • ==I ADP receptors ==> decreased GIIb/GIIIa on platelets ==> decreased clot formation

14

Urokinase: MOA

  • ~tPA
  • acts to convert plasminogen ==> plasmin

15

Alteplase: MOA, uses

  • = tPA ==> plasminogen ==> plasmin
  • uses
    • early MIs (if percutaneous coronary intervention is not available)
    • early ischemic stroke
    • contraindicated if >3 hours have passed since onset of sx, or if pt. has abnormal lab values, high BP, or recent surgery

16

First-line tx for testicular carcinoma + SE

  • Bleomycin
    • induces oxygen radicals during G2 ==> DNA damage ==> arrest of cell cycle
  • SE
    • alopecia
    • skin changes
    • pulmonary toxicity
      • rales, cough
      • interstitial fibrosis

Decks in USMLE Step 1 Class (97):