Flashcards in Rx_2.9 (Renal) Deck (12)
Loading flashcards...
1
Hemoptysis + anemia + renal fail ==> dx/
- goodpasture's syndrome (most likely)
- consider vasculitis
- anti-GBM antibodies ==> damage @ lung and kidney basement membranes
- consider vasculitis
2
First-line therapy for UTIs
TMP-SMZ
3
TMP-SMZ: MOA, SE
- MOA: inhibits folate synthesis ==> inhibition of of nucleotide synthesis
- SE
- megaloblastic anemia
- enlarged red cells
- PMN w/hypersegmented nucleus
- megaloblastic anemia
- enlarged red cells
- PMN w/hypersegmented nucleus
4
Adult polycystic kidney disease inheritance
AD
5
Biopsy findings in PSGN
- enlarged, hypercellular glomeruoli
- dense humps on epithelial side of GBM
6
alpha-ketoacid dehydrogenase deficiency ==> Dx?/Tx?
- Maple Syrup Urine Disease
- enzyme deficiency ==> inability to catabolize branched-chain amino acids
- Isoleucine
- Leucine
- Valine
- ("I Love Vermont's Maple Syrup)
- Tx = avoid consumption of these amino acids
- Isoleucine
- Leucine
- Valine
- ("I Love Vermont's Maple Syrup)
7
Presentation of cystinuria
- defect @ amino acid reabsorption @ proximal tubule ==> wasting of lysine, arginine, cystine, ornithine
- elevated cystine ==> recurrent nephrolithiasis formation
8
Tx of cystinuria
- hydration
- acetazolamide ==> alkalization of urine
9
Dosage adjustments in patients w/impaired renal or hepatic fxn
- same loading dose, decreased maintenance dose
- LD = (CP x Vd)/F
- MD = (Cp x CL x t)/F
- CL = clearance
- t = dosing interval
- CL = clearance
- t = dosing interval
10
First step in MCD
- immediate tx w/steroids
- renal biopsy indicated if failure of steriods
11
Tx for goodpasture's
- corticosteroids
- cyclophosphamide
12
Alport disease presentation
- inherited mutation @ Type IV collagen
- important @ eyes, ears, kidneys
- present @ early childhood w/:
- ocular defects
- defness
- hematuria
- important @ eyes, ears, kidneys
- ocular defects
- defness
- hematuria
