Rx_1.27 (Reproductive) Flashcards Preview

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Flashcards in Rx_1.27 (Reproductive) Deck (17)
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1

Formation of gametes in female

  • Primordial germ cells differentiate into oogonia during embryonic period
  • oogonia replicate DNA and then enter prophase I = primary oocyte
    • occurs by 5 months of fetal development
  • oocytes remain arrested in prophae I until stimulated just prior to ovulation by FSH
  • oocytes ==> metaphase II + LH surge ==> ovulation
  • oocytes arrested @ metaphase II until fertilization

2

Consequences of PCOS

  • oligo/anovulation + hyperandrogenism
  • excess LH + androgens
  • features
    • ovarian cysts
    • amenorrhea
    • intertility 
    • obesity
    • hirsutism
  • associated w/insulin resistance (hyperglycemia) and hyperinsulinemia
  • ==> amenhorrea and infertility

3

Standard management of PCOS

  • weight loss
  • OCPs
  • gonadotropin-releasing hormone analogs
  • tx of insulin resistance

4

Virulence mediator in gonorrhoeae

  • presentation = gram (-) diplococci w/in PMNs
  • variable antigenic pili ==> attachment to mucosal surfaces
    • variation in antigens aids in evasion of host defenses

5

Twins in utero:

division w/in 3 days

division between 4-8 days

division between 8-12 days

  • division w/in 3 days ==>
    • monozygotic OR dizygotic twins
    • diamniotic
    • dichorionic
    • 2 placentas
  • division @ 4-8 days ==>
    • monozygotic twins
    • diamniotic
    • monochorionic
    • one placenta
  • division @ 8-12 days ==>
    • monozygotic twins
    • monoamniotic
    • monochorionic
    • one placenta

6

Hormone necessary for development of external genitalia in males

  • dihydrotestosterone (DHT)
    • Testosterone ==5a-reductase==> DHT

7

Fxn of FSH and LH in males

  • FSH ==> maintains spermatogenesis
  • LH ==> acts at testes to stimulate testosterone production

8

Fxn of Mullerian inhibiting factor and testosterone in males in utero

  • MIF ==> regression/prevention of formation of female internal genital organs from Mullerian ducts
  • Testosterone ==> maintenance of Wolffian ducts in males ==> form male urogenital organs

9

Preeclampsia presentation

  • classic triad = HTN, edema, proteinuria in pregnant patietns >20 weaks 
  • more common @ patients w/DM, chronic renal dz, autoimmune, pre-existing HTN

10

Signs of severe preeclampsia

  • HELLP:
  • Hemolysis
  • Elevated Liver fxn tests
  • Low Platelets

11

Dx of eclampsia

  • preeclampsia + maternal seizures
    • can be dx via EEG

12

Tx of preeclampsia

  • antihypertensives
  • deliver @ 34 wks (if severe) or @ 37 wks (if mild)
  • IV magnesium sulfate to prevent seizures

13

Vaginal bleeding at postmenopausal women ==>?

cancer [endometrial carcinoma] until proven otherwise

14

Which cell is indicated by the arrow [w/in seminiferous tubules]?

  • Sertoli cell = supportive/nutritive role in spmatogenesis but is not spermatogenic

15

Nonspermatogenic cells @ seminferous tubules + roles/location

  • Sertoli cells
    • location: line seminferous tubules
    • in utero: secrete MIF
    • secrete inhibin ==> inhibit FSH
    • support/nourish spermatozoa
    • regulate local levels of androgens
      • convert T ==> estrogen (via aromatase)
  • Leydig cells
    • location: interstitium
    • Secrete testosterone in presence of LH

16

Most specific test for dx of syphillis

Flourescent treponemal antibody absorption test

17

Wil-Felix rxn =

  • classic test for rickettsial infection
  • e.g. Rocky Mountain spotted fever

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