Pathoma Carcinogenesis I Flashcards Preview

USMLE Step 1 > Pathoma Carcinogenesis I > Flashcards

Flashcards in Pathoma Carcinogenesis I Deck (23)
1

Carcinogens

Damage DNA

2

Aflatoxins (from aspergillus - stored rice, grains)

Hepatocellular Carcinoma

3

Alkylating Agents

Leukemia/Lymphoma

4

Alcohol

SCC of oropharynx, upper esophagous, HCC Pancreatic carcinoma

5

Arsenic

SCC skin (old timer women-put on skin) Lung cancer (cigarette smoke)

6

Asbestos

Lung carcinoma (more likely) Mesothelioma

7

Cigarette smoke (Polycyclic hydrocarbons***)

Carcinoma of Oropharynx Carcinoma of Lung Carcinoma of Kidney Carcinoma of Bladder Carcinoma of Pancreas

8

Nitrosamines

Stomach carcinoma (Japan-smoked foods) (Intestinal type)

9

Naphthylamine (Cigarette smoke****)

Urothelial carcinoma of the bladder

10

Vinyl chloride (PVC)

Angiocarcinoma of the liver

11

Nickel, Chromium, Beryllium, Silica (occupational exposure)

Lung carcinoma

12

EBV

Nasopharygeal carcinoma Burkitt lymphoma CNS lymphoma (AIDS)

13

Nasopharygeal carcinoma Cx

Chinese Male, African male Neck mass

14

HHV-8

Kaposi Sarcoma (tumor of endothelial cells)

15

Who gets Kaposi sarcoma?

Eastern European males (excise) AIDS patients (treat HIV) Transplants (reduce immunosupression)

16

HBV, HCV (DNA, RNA)

Hepatocellular carcinoma

17

HTLV-1

Adult T-cell leukemia/lymphoma

18

HPV (16, 18)

SCC vulva, vagina, anus, cervix, adenocarcinoma of the cervix

19

Ionizing radiation (nuclear accident)

AML CML Papillary carcinoma of the thyroid

20

Ionizing radiation mechanism

via hydroxyl free radicals

21

Nonionizing radiation (UVB)

Basal cell carcinoma SCC Melanoma of the skin

22

Nonionizing radiation mechanism

Pyrimidine dimers in DNA Excised by restriction endonuclease

23

Disease where restriciton endonucleases are non-functioning, leads to high likelihood of skin cancer?

Xeroderma Pigmentosum

Decks in USMLE Step 1 Class (97):