Flashcards in Pathoma Carcinogenesis I Deck (23)
1
Carcinogens
Damage DNA
2
Aflatoxins (from aspergillus - stored rice, grains)
Hepatocellular Carcinoma
3
Alkylating Agents
Leukemia/Lymphoma
4
Alcohol
SCC of oropharynx, upper esophagous, HCC Pancreatic carcinoma
5
Arsenic
SCC skin (old timer women-put on skin) Lung cancer (cigarette smoke)
6
Asbestos
Lung carcinoma (more likely) Mesothelioma
7
Cigarette smoke (Polycyclic hydrocarbons***)
Carcinoma of Oropharynx Carcinoma of Lung Carcinoma of Kidney Carcinoma of Bladder Carcinoma of Pancreas
8
Nitrosamines
Stomach carcinoma (Japan-smoked foods) (Intestinal type)
9
Naphthylamine (Cigarette smoke****)
Urothelial carcinoma of the bladder
10
Vinyl chloride (PVC)
Angiocarcinoma of the liver
11
Nickel, Chromium, Beryllium, Silica (occupational exposure)
Lung carcinoma
12
EBV
Nasopharygeal carcinoma Burkitt lymphoma CNS lymphoma (AIDS)
13
Nasopharygeal carcinoma Cx
Chinese Male, African male Neck mass
14
HHV-8
Kaposi Sarcoma (tumor of endothelial cells)
15
Who gets Kaposi sarcoma?
Eastern European males (excise) AIDS patients (treat HIV) Transplants (reduce immunosupression)
16
HBV, HCV (DNA, RNA)
Hepatocellular carcinoma
17
HTLV-1
Adult T-cell leukemia/lymphoma
18
HPV (16, 18)
SCC vulva, vagina, anus, cervix, adenocarcinoma of the cervix
19
Ionizing radiation (nuclear accident)
AML CML Papillary carcinoma of the thyroid
20
Ionizing radiation mechanism
via hydroxyl free radicals
21
Nonionizing radiation (UVB)
Basal cell carcinoma SCC Melanoma of the skin
22
Nonionizing radiation mechanism
Pyrimidine dimers in DNA Excised by restriction endonuclease
23