Rx_2.4 Flashcards Preview

• HPV
• E6 ==> p53
• E7 ==> Rb

1. heart disease
2. malignancy
3. stroke

MVCs

1. Ethanol ==> acetylaldehyde 
   1. Alcohol dehydrogenase + NAD⁺ (cofactor)
      1. inhibited by fomepizole [used in suspected methanol or ethylene glycol poisoning]
2. Acetylaldehyde ==> acetate
   1. Acetylaldehyde dehydrogenase + NAD⁺ (cofactor)
      1. inhibited by disulfuram ==> acetylaldehyde accumulation ==> disulfuram rxn

• postpartum blues = 
  • fatigue
  • anxiousness about the infant
  • weeping, emotional lability
  • irritability
  • usually resolves w/10 days
• postpartum depression =
  • more serious
  • ~MDD
  • feelings of hopelessness and anhedonia
  • lasts 2 weeks to a year or more

• B-cell neoplasm ==> monoclonal M spike on serum protein electrophoresis
• ==> weakness, weight loss
• excess IgM protein ==> hyperviscosity syndrome ==> damage of small vessels
  • headaches
  • visual disturbances
  • nosebleeds

• monoclonal M spike (IgG, IgA)
• lytic bone lesions ==> bone pain, hypercalcemia
• renal insufficiency, azotemia
• increased susceptibility to infection and anemia
• immunoglobulin light chain (Bence Jones' protein) @ urine
• rouleax formation of RBCs on peripheral smear

• intussusception = telescoping of one segment of bowl into another ==> obstruction
• common @ children 1-5yo