Flashcards in Rx_2.4 Deck (8)
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1
Virus that leads to neoplasm by inactivating p53 and Rb
- HPV
- E6 ==> p53
- E7 ==> Rb
2
Top 3 common causes of death in people > 65yo
- heart disease
- malignancy
- stroke
3
Most common cause of death among children/adolescents
MVCs
4
Metabolism of ethanol
- Ethanol ==> acetylaldehyde
- Alcohol dehydrogenase + NAD+ (cofactor)
- inhibited by fomepizole [used in suspected methanol or ethylene glycol poisoning]
- Acetylaldehyde ==> acetate
- Acetylaldehyde dehydrogenase + NAD+ (cofactor)
- inhibited by disulfuram ==> acetylaldehyde accumulation ==> disulfuram rxn
- Alcohol dehydrogenase + NAD+ (cofactor)
- inhibited by fomepizole [used in suspected methanol or ethylene glycol poisoning]
- Acetylaldehyde dehydrogenase + NAD+ (cofactor)
- inhibited by disulfuram ==> acetylaldehyde accumulation ==> disulfuram rxn

5
Postpartum depression vs. postpartum blues
- postpartum blues =
- fatigue
- anxiousness about the infant
- weeping, emotional lability
- irritability
- usually resolves w/10 days
- postpartum depression =
- more serious
- ~MDD
- feelings of hopelessness and anhedonia
- lasts 2 weeks to a year or more
- fatigue
- anxiousness about the infant
- weeping, emotional lability
- irritability
- usually resolves w/10 days
- more serious
- ~MDD
- feelings of hopelessness and anhedonia
- lasts 2 weeks to a year or more
6
Characteristics/presentation of waldenstrom's macroglobulinemia
- B-cell neoplasm ==> monoclonal M spike on serum protein electrophoresis
- ==> weakness, weight loss
- excess IgM protein ==> hyperviscosity syndrome ==> damage of small vessels
- headaches
- visual disturbances
- nosebleeds
- headaches
- visual disturbances
- nosebleeds
7
Multiple myeloma presentation
- monoclonal M spike (IgG, IgA)
- lytic bone lesions ==> bone pain, hypercalcemia
- renal insufficiency, azotemia
- increased susceptibility to infection and anemia
- immunoglobulin light chain (Bence Jones' protein) @ urine
- rouleax formation of RBCs on peripheral smear
8
Presentation of intussusception