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Flashcards in Rx_2.4 Deck (8)
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1

Virus that leads to neoplasm by inactivating p53 and Rb

  • HPV
  • E6 ==> p53
  • E7 ==> Rb

2

Top 3 common causes of death in people > 65yo

  1. heart disease
  2. malignancy
  3. stroke

3

Most common cause of death among children/adolescents

MVCs

4

Metabolism of ethanol

  1. Ethanol ==> acetylaldehyde 
    1. Alcohol dehydrogenase + NAD+ (cofactor)
      1. inhibited by fomepizole [used in suspected methanol or ethylene glycol poisoning]
  2. Acetylaldehyde ==> acetate
    1. Acetylaldehyde dehydrogenase + NAD+ (cofactor)
      1. inhibited by disulfuram ==> acetylaldehyde accumulation ==> disulfuram rxn

5

Postpartum depression vs. postpartum blues

  • postpartum blues = 
    • fatigue
    • anxiousness about the infant
    • weeping, emotional lability
    • irritability
    • usually resolves w/10 days
  • postpartum depression =
    • more serious
    • ~MDD
    • feelings of hopelessness and anhedonia
    • lasts 2 weeks to a year or more

6

Characteristics/presentation of waldenstrom's macroglobulinemia

  • B-cell neoplasm ==> monoclonal M spike on serum protein electrophoresis
  • ==> weakness, weight loss
  • excess IgM protein ==> hyperviscosity syndrome ==> damage of small vessels
    • headaches
    • visual disturbances
    • nosebleeds

7

Multiple myeloma presentation

  • monoclonal M spike (IgG, IgA)
  • lytic bone lesions ==> bone pain, hypercalcemia
  • renal insufficiency, azotemia
  • increased susceptibility to infection and anemia
  • immunoglobulin light chain (Bence Jones' protein) @ urine
  • rouleax formation of RBCs on peripheral smear

8

Presentation of intussusception

  • intussusception = telescoping of one segment of bowl into another ==> obstruction
  • common @ children 1-5yo

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