UWorld_4.7 Flashcards Preview

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Flashcards in UWorld_4.7 Deck (15)
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1

Anti-arrhythmics with use-dependence

  • class I -- esp. class IC

2

Verapamil: MOA, use, SE

  • MOA: non-dihydropyrimadine Ca2+ channel blocker
    • more specificity to heart vs. nifedipine
    • slows conduction through AV node
  • use: Afib with reentrant
  • SE
    • constipation
    • gingival hyperplasia
    • AV node block

3

PMNT purpose and control

  • PMNT = phenylethanolamine-N-methyltransferase
  • synthesizes Epi from NE 
  • under control of cortisol ==> increased gene expression of PMNT

4

Anti-metabolite drugs 

  • folate antagonist
    • methotrexate
  • purine analogs
    • thiopurines (6-MP, 6-GP
    • Fludarabine ==> CLL
    • Cladribine ==> HCL
      • adenosine analog resistant to adenosine deaminase
  • pyrimadine analogs
    • 5-FU
    • Capecitabine
    • Cytaribine
    • Gemcitabine

5

Most common cause of native valve endocarditis

  • mitral valve prolapse
  • rheumatic fever possible, but less common in US due to tx of Strep A with antibiotics

6

Most important pathogenic mechanism for shigella

  • 1. mucosal invasion
  • 2. exotoxin ==> increased virulence + HUS [but not most important]

7

Characteristics of PBC

  • autoimmune destruction of liver bile ducts + cholestasis
  • usually @ middle-aged women, insidious onset
  • initial sx: pruritis and fatigue
  • progression: jaundice, steatorrhea, portal HTN, osteopenia
  • PE: hepatosplenomegaly and evidence of cholestasis (xanthelasma, pale stool)

8

Cause of cutaneous flusing with niacin + tx

  • due to prostaglandin release
  • tx = pretreat with aspirin

9

Bioavailability calculation

F = (AUC oral x IV dose)/(AUC IV x oral dose)

10

Patients for whom ACE-i are contraindicated

bilateral renal artery stenosis/renal artery stenosis + atherosclerosis

11

Main antiviral agent that does not require intracell phosphorylation to be active

foscarnet

12

Polyethylene glycol laxative type? + similar disease process

  • osmotic laxative
  • also -- MgOH
  • lactase deficiency ==> osmotic diarrhea

13

Anti-arrhythmics that ==> QT prolongation

  • quinidine
  • procainamide
  • disopyramide
  • ibutilide
  • defetilide
  • sotalol

14

Beurger's disease

  • vasculitis in smokers; aka thromboangiitis obliterans
    • rxn to injected tobacco extract 
  • small-medium vessel vasculitis; mostly @ tibial and radial arteries
  • histo = acute+ chronic inflammation; segmental thrombosis can extend into contigous veins and nerves

15

_____ ==> similar presentation to Friedrich Ataxia

vit E deficiency

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