Rx_2.10 (Renal) Flashcards Preview

USMLE Step 1 > Rx_2.10 (Renal) > Flashcards

Flashcards in Rx_2.10 (Renal) Deck (13)
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1

Nephrolithiasis associated w/pyelo or UTIs

  • urease positive (Proteus, Klebsiella, or Staph) organisms ==> increased urinary pH + formation of ammonium magnesium phosphate (struvite) stones
  • ==> staghorn calculi

2

Hypercalciuria ==>

  • calcium oxalate stone
  • calcium phosphate stone

3

hypercystinuria ==>

  • cysteine stones
  • due to AR defect in amino acid transport

4

hyperuricemia ==>

  • uric acid stones <== radiolucent
  • due to gout, leukemia

5

Location of WT1 gene

  • wilms tumor
  • chromosome 11

6

WAGR complex?

  • Wilm's tumor
  • Aniridia
  • Genitourinary malformation
  • mental-motor Retardation

7

Histo results of infiltrate in pyelo?

PMNs

8

Thiazide side effect + tx

  • ==> metabolic alkalosis
  • due to volume depletion and increased electrolye exretion
  • dehydration ==> increased K, decreased Na, decreased bicarbonate secretion ==>
    • hypoK
    • hypoCl
  • Tx = normal saline

9

Association w/small cell carcinoma ==> ?

  • SIADH
  • ADH
    • V1 ==> vascular sm m. contraction
    • V2 ==> increased luminal aquaporin density @ distal tubule + collecting duct ==> increased water retention

10

NSAID impact at afferent arteriole

  • inhibit PGE synthesis ==> inhibition of dilation ==> constriction

11

BP medication contraindicated in pregnancy

  • ACE-i
  • can ==> renal agenesis ==> Potter syndrome

12

Acute serum sickness characteristics

  • Type III hypersensitivity rxn
  • ab-antigen complexes produce tissue damage

13

SLE mechanism of damage @ kidney

Type III hypersensitivity/immune complex deposition

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