NSAIDs, Acetaminophen, DMARDs, and Drugs Used in Gout Flashcards Preview

P Pha T > NSAIDs, Acetaminophen, DMARDs, and Drugs Used in Gout > Flashcards

Flashcards in NSAIDs, Acetaminophen, DMARDs, and Drugs Used in Gout Deck (20):
1

Can be used to decrease fever due to cancer: (2)

Ibuprofen
Naproxen

2

Nonselective (COX 1>>>2) NSAID used for the closure of patent ductus arteriosus. Sid effects include aplastic anemia and thrombocytopenia.

Indomethacin

NOTE:
Alprostadil (PGE-1) keeps PDA open.

3

COX-2 selective NSAIDs with side effect of MI and stroke: (2)

Rofecoxib
Valdecoxib

4

Analgesic which selectively inhibits COX-3 inhibitor (weak COX-1 and COX-2 inhibitor); inhibits prostaglandin synthesis; no anti-inflammatory effect.
Side effects include methemoglobinemia, and hemolytic anemia.
Limit per day: _________________
Antidote: __________________

Paracetamol a.k.a. Acetaminophen
4g/day
N-acetylcysteine

5

Drug of choice for rheumatoid arthritis
MOA: inhibits ___________________ and __________________, with secondary effects on polymorphonuclear chemotaxis
Rescue agent: ________________

Methotrexate
AICAR transformylase, thymidilate synthetase
Leucovorin (folinic acid)

6

DMARD used for Chron's disease, rheumatoid arthritis, and other rheumatic diseases
MOA: Binds to ___________ and prevents it from activating its corresponding receptor
Side effects include bacterial infections (URTIs) and reactivation of latent tuberculosis
With synergistic effects with ______________

Infliximab
SimD: Adalimumab, certolizumab, golimumab, etanercept

TNF-alpha
methotrexate

7

DMARD which cannot be given with allopurinol
MOA: Forms ________________, suppressing inosinic acid synthesis, B-cell and T-cell function, immunoglobulin production, and interleukin-2 secretion
Side effects include bone marrow suppression.

Azathioprine
6-thioguanine

8

DMARD used for rheumatoid arthritis or malaria
with ocular toxicity as side effect

Chloroquine

SImD: hydroxychloroquine

9

_____________
A DMARD / chemotherapeutic agent with hemorrhagic cystitis as side effect.
Active metabolite responsible for hemorrhagic cystitis? _________
Rescue agent? ____________

Cyclophosphamide
Acrolein
MESNA

10

DMARD
SE: nephrotoxicity, gingival hyperplasia, hirsutism

Cyclosporine

11

DMARD
SE: reversible myelosuppression (neutropenia)

Mycophenolate mofetil

12

DMARD
For RA, inflammatory bowel disease
SE: hemolytic anemia, methemoglobinemia, reversible infertility in men

Sulfasalazine

13

DMARD
A monoclonal antibody targeted against CD20 B lymphocytes

Rituximab

14

DMARD
Reduces number of T lymphocytes, inhibits macrophage function, decrease IL-1, decreases rheumatoid factor and prevents collagen from cross-linking

Penicillamine

15

Antigout drug (microtubule assembly inhibitor)
SE: diarrhea, hepatic necrosis, acute renal failure, agranulocytosis

Colchicine

16

NSAIDs in Gout
- in addition to inhibiting prostaglandin synthase, they also inhibit urate crystal phagocytosis
- _________ is not used due to its renal retention of uric acid at low doses
- _________ is commonly used in the initial treatment of gout as the replacement of colchicine

Aspirin
Indomethacin

17

Antigout (uriscosuric agent)
SE: GI irritation, aplastic anemia, nephrotic syndrome
May precipitate acute glut during early phase of drug action (prevent by coadministering with colchicine and endomethacin)
Inhibit secretion of other weak acids

Probenecid
SimD: Sulfinpyrazone

18

_________________
Antigout (XOI)
IRREVERSIBLY inhibits xanthine oxidase and lowers production of uric acid
Active metabolite? ___________
First line treatment for CHRONIC gout, tumor lysis syndrome
SE: cataracts
Inhibits metabolism of mercaptopurine and azathioprine
Withheld for 1-2 weeks after an acute episode of hourly arthritis

Allopurinol
Alloxanthine

19

XOI
Reversible inhibitor of xanthine oxidase

Febuxostat

20

A novel irate-lowering recombinant mammalian irate oxidase enzyme

Pegloticase

Decks in P Pha T Class (62):