Flashcards in NSAIDs, Acetaminophen, DMARDs, and Drugs Used in Gout Deck (20):
Can be used to decrease fever due to cancer: (2)
Nonselective (COX 1>>>2) NSAID used for the closure of patent ductus arteriosus. Sid effects include aplastic anemia and thrombocytopenia.
Alprostadil (PGE-1) keeps PDA open.
COX-2 selective NSAIDs with side effect of MI and stroke: (2)
Analgesic which selectively inhibits COX-3 inhibitor (weak COX-1 and COX-2 inhibitor); inhibits prostaglandin synthesis; no anti-inflammatory effect.
Side effects include methemoglobinemia, and hemolytic anemia.
Limit per day: _________________
Paracetamol a.k.a. Acetaminophen
Drug of choice for rheumatoid arthritis
MOA: inhibits ___________________ and __________________, with secondary effects on polymorphonuclear chemotaxis
Rescue agent: ________________
AICAR transformylase, thymidilate synthetase
Leucovorin (folinic acid)
DMARD used for Chron's disease, rheumatoid arthritis, and other rheumatic diseases
MOA: Binds to ___________ and prevents it from activating its corresponding receptor
Side effects include bacterial infections (URTIs) and reactivation of latent tuberculosis
With synergistic effects with ______________
SimD: Adalimumab, certolizumab, golimumab, etanercept
DMARD which cannot be given with allopurinol
MOA: Forms ________________, suppressing inosinic acid synthesis, B-cell and T-cell function, immunoglobulin production, and interleukin-2 secretion
Side effects include bone marrow suppression.
DMARD used for rheumatoid arthritis or malaria
with ocular toxicity as side effect
A DMARD / chemotherapeutic agent with hemorrhagic cystitis as side effect.
Active metabolite responsible for hemorrhagic cystitis? _________
Rescue agent? ____________
SE: nephrotoxicity, gingival hyperplasia, hirsutism
SE: reversible myelosuppression (neutropenia)
For RA, inflammatory bowel disease
SE: hemolytic anemia, methemoglobinemia, reversible infertility in men
A monoclonal antibody targeted against CD20 B lymphocytes
Reduces number of T lymphocytes, inhibits macrophage function, decrease IL-1, decreases rheumatoid factor and prevents collagen from cross-linking
Antigout drug (microtubule assembly inhibitor)
SE: diarrhea, hepatic necrosis, acute renal failure, agranulocytosis
NSAIDs in Gout
- in addition to inhibiting prostaglandin synthase, they also inhibit urate crystal phagocytosis
- _________ is not used due to its renal retention of uric acid at low doses
- _________ is commonly used in the initial treatment of gout as the replacement of colchicine
Antigout (uriscosuric agent)
SE: GI irritation, aplastic anemia, nephrotic syndrome
May precipitate acute glut during early phase of drug action (prevent by coadministering with colchicine and endomethacin)
Inhibit secretion of other weak acids
IRREVERSIBLY inhibits xanthine oxidase and lowers production of uric acid
Active metabolite? ___________
First line treatment for CHRONIC gout, tumor lysis syndrome
Inhibits metabolism of mercaptopurine and azathioprine
Withheld for 1-2 weeks after an acute episode of hourly arthritis
Reversible inhibitor of xanthine oxidase