Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Nefrologia PT > Primary Glomerulonephritis > Flashcards

Primary Glomerulonephritis Flashcards

(75 cards)

Start Studying
1
Q

3 layers of glomerular capillary wall

A

Endothelial cells, GBM, Epithelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

the last barrier resistance encounteted by water and filtered solute

A

epithelial filtration slit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

dominant infiltrating cells in early and late chronic renal injury

A

macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

second most abundantly excreted protein

A

Immunoglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

mild transient proteinuria of less than 1g per day in stressful conditions

A

isolated proteinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

absence of proteinuria in recumbent, less than 1-2 g protein during upright posture

A

orthostatic proteinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

diagnosis of orthostatic proteinuria in split collection 16h vs 8h recumbent

A

protein during recumbency <50 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

normal mesangiun contain about number of mesangial cells

A

2 to 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Dose of prednisone for adult patients witg mcd and duration

A

1 mg/kg not to exceed 80 mg per day, 16weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

predilection for sclerosis in the perihilar regions with hyalinosis, obesity

A

FSGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

segmental consolidation confined to the segment adjacent to the origin of the proximal tubule

A

Glomerular tip variant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Segmental collapse of capillaries with hypertrophy and hyperplasia of overlying podocytes and accumulation of protein resorption droplets

A

Collapsing variant

Most aggressive type of FSGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Presence of mesangial immune complex deposuts with staining for C1q in a patient with no clinical and lab evidence for sle

A

C1q Nephropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Membranous nephropathy caused by antibodies specific for what antibodies?

A

M type Phospholipase A2 receptor

subepithelial immune complex deposits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

mesangial dense deposits in MN

A

secondary MN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

characteristic IF finding in MN

A

diffuse global granular capillary wall staining

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

most frequent and most intense IF staining in MN

A

IgG, IgG4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

characteristic histologic abnormality by light microscopy of MN

A

diffuse global capillary wall thickening in absence of significant glomerular hypercellularity

Caused by immune complex localization in the subepithelial zone of glomerular capillaries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

2 categories of MPGN

A

Immune complex mpgn and c3 glomerulopatht (alternative complement pathway)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Type 2 MPGN

A

dense deposit disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

tran tracking/basement membrane reduplication

lobular glomerulonephritis

A

MPGN Type 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

aggregates of immune complexes filling capillary lumens possibility of crypglobulinemia or lupus in mpgn

A

hyaline thrombi

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

characteristic pattern of if in MpGN

A

peripheral granular to bandlike staining for c3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

mesangial interposition into an expanded subendothelial zone that contain electron dense immune complex deposits

A

MPGN type 1

mesangiocapillary gn

Type of MPGN with persistent depression of C3 and presence of nephritic syndrome Type 1 MPGN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
resembles type 1 Mpgn but with irregularly thickened gbms with numerous intramembranous deposits
mpgn type 3
26
discontinuous electron dense bands within the gbm intense capillary wall linear to bandlike staining for C3
dense deposit disease
27
most common mechanism in uncontrolled activation of C3 convertase
presence of C3NeF
28
psgn associated with skin infections
epidemic psgn
29
psgn with pharyngitides
sporadic psgn
30
IF pattern, numerous large, closely apposed, granular deposits along capillary walls; nephrotic range proteinuria
Garland Pattern
31
IF pattern, psgn More scattered granular staining less severe disease
Starry sky pattern
32
iF pattern, psgn, resolving phase with a mesangioproloferative light microscopic appearance
Mesangial pattern
33
hallmark ultrastructural feature of psgn
subepithelial humplike dense deposits
34
deposition predominantly of IgA in the mesangium with mesangial proliferation focal or diffuse mesangial hyper cellularity without more complex endo capillary hypercellularity
IgA nephropathy
35
four parameters predictive of clinical outcomes in IgA nephropathy
MEST mesangial hypercellularity endocapillary hypercellularity Segmental glomerulosclerosis tubular atrophy and interstial fibrosisb
36
in MEST, **not** significantly predictive of the rate of decline of kidney function or survival from eskd
**endo capillary hypercellularity**
37
size fibrils in fibrillary gn
20 nm
38
size of microtubular structures jn immunotactoid gn
30-40 nm
39
associated with lymphoproliferative disease and monoclonal gammopathy
fibrillary/immunotactoid gn
40
most common cause of rpgn in children
immune complex crescentic gn
41
least frequent cause of crescentic gn
Anti-GBM
42
Linear GBM IF staining + lung hemorrhage proliferative crescentic gn + pulmonary hemorrhage + anti gbm antibodies
good pasture syndrome mpo-anca
43
Anca disease + vasculitis with no granuloma or asthma
microscopic polyangitis
44
Vasculitis with granuloma no asthma Earliest lesions are intracapillary thrombosis with deposition of eosinophilic fibrinoid material with endothelial cell swelling
granulomatosis with polyangitis
45
Vasculitis with granulomas and asthma
Eosinophilic grabulomatosis with polyangitis
46
hallmark ultrastructural finding in immune complex mediated gn
immune complex type electron dense deposit
47
most common biopsy in antigbm
diffuse crescentic gn with more than 50% of glomeruli with exuberant circumferential crescents
48
Intense and diffuse linear staining for igG
Anti-GBM
49
major prognostic marker for progression to eskd in anti-gbm
serum crea at time of tx
50
major pathogenic factor for pauci immune crescentic gn
anca igg
51
endothelial tubuloreticular inclusions seen in
HIV
52
most frequent genetic cause of steroid resistant nephrotic syndrome
NPHs2 podocin
53
strongest indicators of progressive disease in MN
persistence of moderate proteinuria
54
Dose of cyclophosphamide for mcd and duration
2 mk for 8-12 weeks
55
Dose of cyclosporine for mcd
5 mk
56
No of glomeruli for adequate diagnosis
glomerular - 5 tubulointerstitial 6-10 transplant: 7
57
Ponticelli protocol
Methlypred 1g/day for the 1st 3 days of each month with daily oral methylpred 0.4 mkd, prednisone 0.5 mkd alternating monthly with chlorambucil 0.2 mkd
58
when to use ponticelli protocol
Moderate (4 and 6g protein) or high risk (\>8g protein)
59
deposits in the retina Along brusch membrane
Dense deposit disease
60
latent period in post pharyngitic cases in psgn
14 to 21 days
61
Synpharingitic episode latency
less than 1 week
62
latency period of psgn after skin infection
14 to 21 days
63
Tx of pauci immune crescentic gn
steroids + cyclophosphamide | (mppt 7mkd x 3 days; pred 1 mkd 1st month, dc 4th-5th; cyclophosphamide 0.5 g/m2)
64
most impt determinant of patient survival
pulmonary hemorrhage
65
most impt predictor of outcome with respect to eskd in pauci immune
crea at time of initiation of tx
66
Medication in gpa as induction only if disease is milld and controllable
methotrexate
67
TNF a blocker in gpa with 80% remission rate but high rate of infections
Infliximab
68
anti CD52 monoclonal antibody for gpa
alemtuzumab
69
vasculitis induced by ptu
Mpa
70
reduction to less than 3.5 g/day protein and 50% decrease from peak proteinuria
Partial remission
71
cytotoxic agent acts largely through alkylation of purine bases
cyclophosphamide
72
inhibitor of inosine monophosphate dehydrogenase
Azathioprine
73
reversible inhibitor of inosine monophosphate dehydrogenase
mycophenolate acid, mycophenolate mofetil
74
adverse effect of craniofacial malformations
MMF
75
anti C5 monoclonal antibody
Eculizumab

Nefrologia PT (112 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions