Reversible Posterior Leukoencephalopathy Syndrome

Question 1

Reversible Posterior Leukoencephalopathy Syndrome

Answer 1

Hypertensive syndrome associated with cerebral edema and symptoms of headaches, vomiting, confusion, seizures, cortical blindness

Question 2

Reversible Posterior Leukoencephalopathy Syndrome

Answer 2

Acute rise in BP results in dilatation of cerebral arteries and arterioles and increase in blood brain barrier permeability leading to brain edema.

Question 3

Reversible Posterior Leukoencephalopathy Syndrome

Answer 3

Underlying causes: immunosuppressive therapy, vasculitis (lupus), pregnancy (eclampsia), kidney failure, severe HTN

Question 4

Reversible Posterior Leukoencephalopathy Syndrome

Answer 4

Diagnosis: magnetic resonant imaging revealing cortico–subcortical areas of hyperintensity involving the occipital and parietal lobes on T2-weighted images.

Question 5

Reversible Posterior Leukoencephalopathy Syndrome

Answer 5

Management: BP control and treatment of underlying diseases

Condition may be reversible, but blindness may persist.