Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Nefrologia PT > Renal Physiology > Flashcards

Renal Physiology Flashcards

(76 cards)

Start Studying
1
Q

effective filtration pressure

A

50 mmHg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

one of the best predictors of a poor outcome in clinical DM

A

decrease in podocyte number

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dissolution or attenuation of mesangial matrix and degradation of MCs by apoptosis or lysis

A

mesangiolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

amount of blood filtered per day by the kidney

A

180 L

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

difference between inner and outer medulla

A

absence of Thin ascending limbs in the inner medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

splitting and basket-weave lamellae of the GBM

A

Alport syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

inhibitor of the TAL transporter NKCC2

A

Furosemide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NCC is expressed in what segment

A

Distal tubule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

majority of cell type in connecting segment

A

CNT tubule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

most abundant cell type in the peritubular interstitium

A

type 1 fibroblasts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

majority of renal innervation

A

efferent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

decline in hydraulic pressure between the renal artery and the glomerular capillaries is greatest along the

A

afferent arteriole

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ability of the arterial smooth muscle to contract and relax in response to increases and decreases in vascular wall tension

A

myogenic reflex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

maintain a hypertonic inferstitial gradient

A

medulla

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Intrinsic ability of the kidney to respond to perturbations that elicits a vasoactive response, which alters renal vascular resistance in the direction that maintain RBF and GFR

A

renal autoregulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

macula densa cells, extraglomerular mesangium and afferent and efferent arterioles of the glomerulus

A

juxtaglomerular apparatus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

primarily responsible for mediating tubuloglomerular feedback

A

adenosine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

humoral response

A

T helper cell 2 - antibody mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

cellular response

A

T helper cell 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

steroid sensitive nephrotic syndrome

A

MCD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

steroid resistant

A

FSGS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Ca dependent phosphatase which dephosphorylates nuclear factor of activated T cells

A

calcineurin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Na K ATPase

A

3 Na out 2 K in

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Type of transport: Na K ATPase

A

primary active transport

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Type of transport: a-KG cotransport
secondary active transport
26
type of transport OAT
tertiary active transport
27
final urinary acidifcation
medullary CD
28
adaptive mechanism for preventing the exposure of cortical tubules to toxic levels of oxygen while permitting a high RBF
AV O2 shunting
29
most vulnerable to ischemic injury segment of the nephron
S3 proximal tubule
30
final pathway to progression of CKD
intrarenal hypoxia
31
% of NaCl reabsorbed in the proximal tubule
60%
32
major determinant of ecf voume
renal excretion of Na Cl
33
primary site of transport regulation
terminal segment of the nephron
34
near isosomotic reabsorption of 2/3 of the glomerular ultrafiltrate
proximal tubule
35
major inhibitor of proximal tubular Na Cl reabsorption
dopamine
36
Most abundant protein in normal human urine
Tamm Horsfall glycoprotein
37
target for thiazide diuretics
DCT
38
primary Na transport pathway in CNT and CCD
Enac
39
highest NaKATPase activity
DCT
40
loss of function mutation in ENAc; severe neonatal wasting, hypotension, acidosis, hyperkalemia
pseudohypoaldosteronism type 1
41
gain of function mutation ENAc, suppressed aldosterone, hypokalemia
Liddle syndrome
42
plays a critical role in medullary K recycling
loop of henle
43
primary site of distal K secretion
CNT- CCD
44
protein that counterbalances PTH
sclerostin
45
metabolic acidosis urinary calcium
increase
46
PTH in low calcium
increase
47
transport of calcium in proximal tubule
pracellular and transcellular
48
loss of function of claudin 16-19
renal ca and mg wasting/FHHNC
49
inactivating mutation in NCC
Gitelman syndrome
50
Bulk of reabsorption of Mg in which nephron segment
Thick ascending limb, paracellular
51
major site of phosphate reabsorption
proximal tubule
52
major site of glucose handling
kidneys
53
loss of function of GLUT2
fanconi bickel syndrome
54
basolateral glucose transporters
GLUT 1 and 2
55
site of greatest renal glucose reabsorption and generation
proximal tubule
56
major anionic transporter
OAT 1 and OAT 3
57
main intestinal uric acid efflux transporter
ABCG2
58
protons are secreted into luminal fluid by
nhe3
59
mutation in NBCe1
Autosomal Recessive proximal RTA
60
Major H+ secretory mechanism in the loop of henle
Na-H exchanger
61
Stimulates HCO3 reabsorption in the TAL
Ang II, mineralocorticoids, hypotonicity
62
Inhibits Hco3 reabsorption
PTH, AVP, hypertonicity
63
final site of HCo3 reabsorption
Collecting Duct
64
mutation in H-ATPase
distal RTA type 1
65
Cl/HCo3 exchanger
pendrin
66
major basolateral anion exchanger in Type A intercalated cell
kAE1
67
predominant titratable acid
phosphate
68
primary site for ammoniagenesis
proximal tubule primary substrate for renal ammoniagenesis glutamine
69
apical transporter, major NH3 reabsorption
NKCC2
70
major sites of parathyroid hormone–mediated calcium absorption
Thick ascending limb, DCT
71
final site of controlling renal acid-base regulation
collecting duct
72
major apical transport Na entry in thick ascending limb
NKCC2
73
earliest site along renal tubule where water absorption increases during antidiuresis
late distal tubule
74
earliest sites of distal tubular osmotic equlibration
CNT, CCD
75
major site of dilution
loop of henle chief site of urine concentration Collecting Duct
76
tubular Reabsorption & secretion:
* In proximal tubules : • 65% of (Na,WATER and chloride)reabsorbed • 100% Glucose & amino acids • 90% of bicarbonate, calcium and K+ reabsorbed * Loop of henle : • 25% of the Na and water reabsorbed * Early distal tubule: • 5-8 % of the Na reabsorbed * In the late distal tubule &coolicting tubule • 3-7% of Na reabsorbed * medullary collecting ducts Reabsorb \<10% of sodium & H2O

Nefrologia PT (112 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions