10.0 Antivirals Flashcards Preview

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Flashcards in 10.0 Antivirals Deck (14):
1

Which antiviral drugs are used for respiratory infections? (5)

1) Oseltamivir
2) Zanamivir
3) Amantadine
4) Rimantadine
5) Ribavirin

2

Which drugs are Neuraminidase inhibitors?

1) Oseltamivir
2) Zanamivir

3

What is the MOA of Neuraminidase inhibitors?

Inhibit release of virus by inhibiting sialic acid substrate.

4

What is important to know about the PK of Oseltamivir?

Orally active prodrug (hydrolyzed in liver)

5

What is important to know about the PK of Zanamivir?

NOT orally active (inhaled, intranasal)

6

What are the adverse effects of Oseltamivir?

GI discomfort
Nausea (alleviated when taken with food)

7

What are the adverse effects of Zanamivir?

Airway irritation (avoid in severe asthma, COPD)

8

Which drugs act exclusively on Influenza A?

Amantadine
Rimantadine

9

What is the MOA of Amantadine/Rimantadine?

Block viral M2 protein

10

Which ion channel blocker crosses the BBB?

Amantadine

11

Which drugs have a 50% natural individual resistance?

Ion Channel Blocker antivirals

12

What is the MOA of Ribavirin?

• Converted to ribavirin-triphosphate which inhibits guanosine triphosphate formation and prevents viral
mRNA capping.

• Inhibits RNA-dependent RNA polymerase resulting in inhibition of viral protein synthesis

13

What category of pregnancy is Ribavirin?

Category X (Most tetratogenic drug)

-even females of male partner are taking it, must make sure they are not pregnant!!!

14

What are the adverse effects of Ribavirin?

• Dose-dependent transient anemia (can bind to RBC)

• GI (nausea, anorexia)

• CNS (fatigue, headache, insomnia)