Hypothalamic and Pituitary Hormones 2.1 Flashcards Preview

Pharmacology > Hypothalamic and Pituitary Hormones 2.1 > Flashcards

Flashcards in Hypothalamic and Pituitary Hormones 2.1 Deck (16):
1

ACTH analogs

Corticotropin
Cosyntropin

2

MOA of ACTH analogs

Stimulate adrenal cortex via MC2 receptor -> increased cAMP -> steroid hormone secretion.

3

Clinical application of ACTH analogs (2)

1) Differentiate between primary and secondary adrenal insufficiency
2) Infantile spasm (West Syndrome) treatment

4

Oxytocin MOA

Acts on GPCRs -> stimulates release of prostaglandins & leukotrienes that augment uterine contraction.

5

Small doses of Oxytocin does what?

Increases force and frequency of contractions

6

Higher doses of Oxytocin does what?

evokes sustained contractions. Weak antidiuretic & pressor activity (vasopressin R activation).

7

How does Oxytocin cause milk ejection?

Contraction of myoepithelial cells surrounding mammary alveoli.

8

Oxytocin IV is used when

Initiation and augmentation of labor

9

Oxytocin IM is used when

control of postpartum bleeding

10

Adverse effects of Oxytocin (3)

1) Excessive stimulation of uterine contraction: fetal distress, placental abruption, uterine rupture

2) Inadvertent activation of vasopressin receptors: excessive fluid retention, water intoxication -> hyponatremia, heart failure, seizures, death.

3) Bolus injections can lead to hypotension

11

Oxytocin contraindications (5)

• Fetal distress
• Prematurity
• Abnormal fetal presentation
• Cephalopelvic disproportion
• Uterine rupture predisposition

12

Oxytocin antagonist

Atosiban

13

Released in response to rising plasma tonicity or falling BP

Vasopressin

14

Long acting synthetic analog of vasopressin with minimal V1 activity

Desmopressin

15

V1R activation (via vasopressin agonists) leads to?

Vascular smooth muscle -> vasocontriction

16

V2R activation (via vasopressin agonists) leads to?

Principal cells in collecting duct stimulate aquaporin 2 upregulation -> increased water permeability & reabsorption.