Flashcards in 10.1 Antivirals Deck (14):
Which classes of antivirals are used for hepatic infections? (3)
2) Nucleotide/Nucleoside analogs
3) Protease Inhibitors
What is the DOC for HSV encephalitis?
What are the 3 steps required for activation of acyclovir?
•Monophosphorylated by herpes virus-encoded enzyme (thymidine kinase)
• Host cell enzymes complete phosphorylation to di- and triphosphate forms
• Competes with dGTP; once incorporated into DNA causes chain termination & inhibition of viral DNA polymerase
How does Acyclovir resistance occur?
• Altered or deficient thymidine kinases
• Altered viral DNA polymerase with decreased affinity for
What is significant about valacyclovir?
Greater oral bio availability
Ganciclovir is the DOC for what?
CMV retinitis & CMV prophylaxis in
What is the MOA of Ganciclovir?
• Phosphorylated by viral (UL97) and cell kinases
• DNA chain terminator & DNA polymerase inhibitor
What are the adverse effects of Gangiclovir?
• Severe dose-dependent neutropenia
Cidofovir is used for what?
-Major use is treatment of CMV-induced retinitis in
-Effective against HSV & ganciclovir resistant HSV
Which purine &pyrimidine analog must be phosphorylated by viral kinases?
Which purine and pyrimidine analog must be activated by host cell kinase instead of viral kinase?
What is Trifluridine the DOC for?
• Drug of choice for HSV keratoconjunctivitis and
recurrent epithelial keratitis
Which drug is used for the topical treatment of HSV (cold sores)