9.1 Anti-Mycobacterials Flashcards Preview

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Flashcards in 9.1 Anti-Mycobacterials Deck (8):
1

Ethambutol inhibits which enzymes?

arabinosyl transferases

2

What is the most important Adverse Effect from Ethambutol?

• Dose-dependent visual disturbances (eg, red/green color blindness) – cannot be used in children too young to receive sight tests

3

Which anti-mycobacterial drug has adverse effects of nongouty polyarthralgia?

Pyrazinamide

4

What is the MOA of Pyrazinamide?

Enzymatically hyrolyzed to active pyrazinoic acid

5

Which 3 drugs are recommended to be used in combination for Leprosy?

• Dapsone
• Clofazimine
• Rifampin

6

What is the mechanism of Dapsone?

• Inhibits folate synthesis (via dihydropteroate synthetase
inhibition)

7

What is acedapsone?

Repository form of dapsone

8

What are the adverse effects of Dapsone?

• Hemolysis (esp. G6PD deficiency)
• Erythema nodosum leprosum (treated with
corticosteroids or thalidomide)
• Other effects – GI irritation, fever, hepatitis,
methemoglobinemia
• Other effects – GI irritation, fever, hepatitis,
methemoglobinemia
• CYP P450 inhibitor