Flashcards in 4.2 Opioids Deck (20):
Which opioid derivatives are most commonly used as antitussives? (2)
Which opioid analgesics are most commonly used to control diarrhea? (2)
Which opioid analgesic has the most pronounced anti-shivering properties?
How does meperidine work?
Blocks shivering by acting on alpha2-adrenoreceptors
What are the most common adverse effects with use of opioid analgesics? (5)
Describe the effects of using a pure agonist alongside a weak partial agonist?
- Risk of diminishing analgesia or even inducing a state of withdrawal.
Why are opioids contraindicated in patients with head injuries?
CO2 retention caused by respiratory depression results in cerebral vasodilation -> brain fxn alteration in pt with inc ICP.
Why are opioids contraindicated in pregnancy?
Fetus may become dependent
Opioids can have drug interactions with which category of drugs?
3) MAO inhibitors
Which opioids do we see drug interactions with when taken alongside MAOIs?
Which opioid drugs are considered strong agonists? (6)
2) Hydromorphone and Oxymorphone
Which opioids are more liposoluble than morphine and enter the brain more readily?
- 6-MAM (product of heroin hydrolysis, which is then converted to morphine.)
Meperidine acts upon which receptor?
Mu receptor agonist
Normeperidine, the metabolic of Meperidine, has a half life of how long?
15-20 hours (compared to 3 hours for meperidine)
Describe the reaction in serotonin syndrome
-Hyper or hypotension
How does meperidine cause serotonin syndrome?
Meperidine blocks serotonin reuptake
Which receptor does Fentanyl act upon?
Does the PK of Fentanyl
Rapid onset and short duration of action (15-30 mins)
How does Fentanyl compare to Morphine?
100 times more potent than morhpine.
Sufentanil (subgroup) is 1000 times more potent