Bone Mineral Homeostasis Flashcards Preview

Pharmacology > Bone Mineral Homeostasis > Flashcards

Flashcards in Bone Mineral Homeostasis Deck (37):
1

concept: what does hypomagnesium do to PTH

decreases --> leads to hypocalcemia

2

concept: what are common causes of hypomagnesium

chornic diarrhoea, diuretics, alcohol abuse, chronic PPI and aminoglycoside use

3

MOA Teriparatide

recombinant PTH that stimulates bone formation if you give it PULSATILE
@ high does - resorption

4

MOA Denosumab

RANK L inhibitior
prevents stimulation of osteoclast

5

A/se Denosumab

increased infection risk

6

Type I Vitamin D dependent Rickets

defective 1alpha hydroxylase

7

Type II vitamin D dependent RIckets

defective receptor

8

Treat Psoriasis

calcipotriol

9

What is cholecalciferol

vitamin D3

10

What is ergocalciferol

vitamin D2

11

MOA Sevelamer

phosphate binding drug --> no absoprtion of dietary phosphate in teh Gi

12

uses of Sevelamer

phosphate binding drug - used to prevent hyperphosphatemia in chronic renal dailure patients

13

Treat overdose of magnesium sulfate in eclampsia please

calcium gluconate IV style

14

A/se estrogen

thromboembolism
migraine
increased risk of breast and endometrial cancer

15

What's a SERM?

Selectie Estrogen Receptor Modulator

16

Name some SERMs

Tamoxifen, Raloxifene

17

Describe Tamoxifen

antag @ breat
agonistic @ bone
agonistic @ bone

18

A/se tamoxifen

increasedk endometrial ca and thrmoboembolism and hot flushes

19

Uses of tamoxifen

breast cancer and beneficial effect on bone

20

Describe Raloxifene

antag at breast
agonist at bone
no estrogenic effect on endometrium

21

Name the bisphosphnates

etriDRONATE
alenDRONATE
pamiDRONATE
riseDRONATE

22

MOA of bisphosphonates

inhibit osteoclasitc activity via decreasing farnesyl pyrophosphate synthesis = disrupts mevlonate pahtway decreased osteoclast HATPase = reduced resorption

23

Which bisphoshonate should not be used long term and why please

Etidronate - dont use it when its late --> bone malformation due to decreased osteoblastic activity

24

What do you use etidronate, alendronate, pamidronate and risedronate for?

osteoporsis
malignancy associated with hypercalceim
Paget disease

25

a/se of bisphosphates DRONATEs

erosive esophagitis

26

a/se of etidronate

osteomalacia
osteonercorsis of jaw and fracures

27

MOA cinacalcet

activates calcium sensing receptors --> leads to decreased PTH

28

uses of cinacalcet

secondary hyperparathyroidism
parathyroid carcinoma

29

Treat parathyroid carcinoma

cinacalcet - stimulates CaSR

30

Flouride it up

chronic exposure - new bone synthesis that is denser but brittle

31

describe gallium nitrate

inhibits bone resoprtion

nephrotoxic


used at cancer-related hypercalcemia

32

Plicamycin/mithracin

cytotoxic acnticancer drug

used at cancer-related hypercalceim (wiht gallim nitrate)

33

cancer related hypercalcemia

plicamycin and gallium nitrate

34

Name the drugs that cause osteoporsis

AACHL
alcohol
Anastrozole
chorticosteroids
heparin
lithium

35

name drugs that cause osteomalacia

phenytoin
etridronate if used for more than 12 months

36

Treat the hypercalcemia

furosemide - diuretic
biophosphonates (DRONATES) inhibit osteoclast activity
calcitonin
parathyroidectomy

37

Treat osteoporosis

stop smoking
stop OH abuse
stop corticosteroids (otehr drugs that can cause - anastrozole, Li and heparin)
calcium and vit B supplementation
bisphosphonates DRONATES
SERMs
terparatide