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Flashcards in 8.0 Deck (15):
1

Penetration of blood brain barrier is influenced by (3)

• lipid solubility of drug (eg, fluoroquinolones &
metronidazole are lipid soluble. Penicillin has low
lipid solubility)

• molecular weight

• protein binding of the drug

2

What are the 3 ways synergy is achieved in combination therapy?

1) Sequential Blockade
2) Block drug inactivating enzymes
3) Enhanced drug uptake.

3

What is an example of a sequential blockade

Trimethoprim + sulfamethoxazole

4

What is an example of a block drug inactivating enzyme?

Clavulanic acid + amoxicillin

5

What is an example of enhanced drug uptake?

Aminoglycosides have increased permeability after B-lactam treatment.

6

What are the complications of antibiotic therapy?

• Hypersensitivity – frequent (urticaria to anaphylactic shock)

• Direct toxicity – directly affect hosts cellular processes
(eg, aminoglycosides & ototoxicity)

• Superinfection – new or secondary infection that occurs
during antimicrobial therapy of a primary infection.

7

Which drugs are considered Cell Wall Synthesis Inhibitors? (5)

1) B-lactams
2) Vancomycin
3) Daptomycin
4) Bacitracin
5) Fosfomycin

8

Which drugs are considered B-lactam antibiotics? (4)

1) Penicillins
2) Cephalosporins
3) Carbapenems
4) Monbactams

9

What is B-Lactamase?

Bacterial enzymes that inhibit antibiotics by binding (hydrolyze) to the b-lactam ring.

10

Which bacterial enzyme does Penicillin activate?

Autolysin -> activates cell wall lysis.

11

Penicillin G is the DOC for? (3)

• Syphilis (benzathine penicillin G)

• Strep infections (especially in prevention of rheumatic fever)

• Susceptible pneumococci

12

Penicillin G Benzathine is the DOC for?

1) Syphillis

2)Rheumatic fever prophylaxsis.

13

Penecillin V is the DOC for? (1)

Strep Throat

14

Which are the Antistaphylococcal Penicillins? (4)

1) Methicillin
2) Nafcillin
3) Oxacillin
4) Dicloxacillin

15

What is unique about antistaphylococcal penicillins?

B-Lactamase resistant