1.2 GI Drugs Flashcards Preview

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Flashcards in 1.2 GI Drugs Deck (20):
1

Which antimicrobials are used in treatment for H.Pylori? (4)

1) Clarithromycin
2) Amoxicillin
3) Metronidazole
4) Tetracycline

2

What combination of drugs are used for H.Pylori infection?

Triple therapy: 2 ABx + PPIs

3

Besides triple therapy, what other combo is used to treat H.Pylori

Bismuth + 2 ABx + PPI or rantidine

4

Which drugs are the mucosal protective agents? (3)

1) Sucralfate
2) Bismuth subsalicylate
3) Misoprostol

5

Which mucosal protective agent is a disaccharide and requires acid to be activated?

Sucralfate

(do not give with PPI's or H2 blockers

6

How does misoprostol work as a mucosal protective agent?

-PGE1 Analogue
- Decreases HCl secretion and increase mucin & bicarb production via activation of Gi therefore dec cAMP.

7

What is the mechanism of mucosal protective agents?

Polymerization and selective binding to necrotic tissue forms a physical barrier to acid

8

Which mucosal agent is approved for NSAID induced ulcers but has been replaced by H2 blockers and PPI's?

Misoprostol

9

What are the adverse effects of misoprostol? (3)

1) Diarrhea
2) Abortion
3) Exacerbation of IBD

10

Which drugs are the prokinetic agents? (5)

1) Bethanechol
2) Neostigmine
3) Metoclopramide
4) Cisapride
5) Erythromycin

11

Which prokinetic agent stimulates ACh secretion?

Cisapride

12

What is the mechanism of action of Cisapride?

5-HT4 agonist

13

What is the MOA of Metoclopramide? (3)

1) 5-HT3 and D2 blocker
3) 5-HT4 = prokinetic

14

Which prokinetic agent is a Motilin receptor agonist?

Erythromycin

15

What is Erythromycin indicated for?

Gastric emptying before endoscopy

16

Which prokinetic agent can cause arrhythmias and should be avoided in patients with long QT syndrome?

Cisapride

17

Which prokinetic agent may develop tolerance in gastroparesis?

Erythromycin

18

Which prokinetic agent has adverse effects of galactorrhea, sedation, diarhea, and extrapyramidal symptoms

Metoclopromide

19

Which prokinetic agent is indicated for pseudoobstruction in hospitalized patients?

Neostigmine

20

Which prokinetic agent is indicated for Gastroparesis, and emesis associated with chemo.

Metoclopromide