Flashcards in 1.2 GI Drugs Deck (20):
Which antimicrobials are used in treatment for H.Pylori? (4)
What combination of drugs are used for H.Pylori infection?
Triple therapy: 2 ABx + PPIs
Besides triple therapy, what other combo is used to treat H.Pylori
Bismuth + 2 ABx + PPI or rantidine
Which drugs are the mucosal protective agents? (3)
2) Bismuth subsalicylate
Which mucosal protective agent is a disaccharide and requires acid to be activated?
(do not give with PPI's or H2 blockers
How does misoprostol work as a mucosal protective agent?
- Decreases HCl secretion and increase mucin & bicarb production via activation of Gi therefore dec cAMP.
What is the mechanism of mucosal protective agents?
Polymerization and selective binding to necrotic tissue forms a physical barrier to acid
Which mucosal agent is approved for NSAID induced ulcers but has been replaced by H2 blockers and PPI's?
What are the adverse effects of misoprostol? (3)
3) Exacerbation of IBD
Which drugs are the prokinetic agents? (5)
Which prokinetic agent stimulates ACh secretion?
What is the mechanism of action of Cisapride?
What is the MOA of Metoclopramide? (3)
1) 5-HT3 and D2 blocker
3) 5-HT4 = prokinetic
Which prokinetic agent is a Motilin receptor agonist?
What is Erythromycin indicated for?
Gastric emptying before endoscopy
Which prokinetic agent can cause arrhythmias and should be avoided in patients with long QT syndrome?
Which prokinetic agent may develop tolerance in gastroparesis?
Which prokinetic agent has adverse effects of galactorrhea, sedation, diarhea, and extrapyramidal symptoms
Which prokinetic agent is indicated for pseudoobstruction in hospitalized patients?