Hypothalamic and Pituitary Hormones 1.3 Flashcards Preview

Pharmacology > Hypothalamic and Pituitary Hormones 1.3 > Flashcards

Flashcards in Hypothalamic and Pituitary Hormones 1.3 Deck (15):
1

Gonadotropins act through what?

GPCR

2

Clinical applications of Gonadotropins

1) Ovulation Induction
2) Male infertility (req both FSH and LH)

3

AE of gonadotropins in Women

1) Ovarian hyperstimulation syndrome
2) Multiple pregnancies
3) Headache, depression edema, precocious puberty

4

AE of gonadotropins in Men

Gynecomastia

5

Gonadorelin

Gonadotropin-releasing hormone

6

Gonadotropin-releasing hormone analogs

1) Goserelin
2) Leuprolide
3) Nafarelin

7

What type of GnRH secretion is required to STIMULATE release of LH and FSH?

Pulsitile

8

What type of GnRH secretion is required to INHIBIT FSH and LH release (men & woman) leading to hypogonadism.

Sustained nonpulsatile

9

What is unique regarding GnRH analog administration?

Biphasic response:
- agonist flare in first 7 days
- chronic effects (> 1 week) = inhibitory action (due to receptor down-regulation & changes in signaling pathways

10

Clinical application of GnRH for males with infertility

In men with hypothalamic
hypogonadotropic hypogonadism (pulsatile gonadorelin)

11

Besides infertility, another stimulation application for GnRH analogs

Diagnosis of LH responsiveness: Whether delayed puberty is due to constitutional delay or hypogonadotropic
hypogonadism

12

Indication for when GnRH and analogs are used for suppression:

1) Controlled ovarian hyperstimulation (leuprolide, nafarelin)
2) Endometriosis (Leuprolide, goserelin, nafarelin)
3) Central Precocious Puberty (leuprolide, nafarelin)
4) Advanced breast & ovarian cancer
5) Treatment of amenorrhea and infertility in women with PCOD
6) Thinning of endometrial lining

13

Notable AE of Gonadorelin

1) Generalized hypersensitivity dermatitis (long term administration)
2) Rare acute hypersensitivity reaction
3) Sudden pituitary apoplexy and blindness (reported in patients with gonadotropin-secreting pit. tumor)

14

Competitive antagonist of GnRH receptors

Centrorelix
Ganirelix

15

Clinical application of GnRH receptor antagonist?

Supression of Gonadotropin Production: Prevention of LH surge during controlled ovarian hyperstimulation