11.0 Antiretrovirals Flashcards Preview

Pharmacology > 11.0 Antiretrovirals > Flashcards

Flashcards in 11.0 Antiretrovirals Deck (15):
1

What are the 3 enzymes in HIV?

1) Protease
2) Integrase
3) Reverse Transcriptase

2

What receptor in HIV is most important for binding?

CCR5

3

When is therapy usually initiated for HIV?

-When CD4+ cells drop less than 500 cells/mm3
or
• Pregnancy
• History of an AIDS-defining illness
• HIV-associated nephropathy (HIVAN)
• HIV/hepatitis B virus (HBV) co-infection

4

Which drugs fall under the class Nucleoside/-tide Reverse Transcriptase Inhibitors (NRTIs)?

Abacavir,
Didanosine,
Emtricitabine,
Lamivudine,
Stavudine,
Tenofovir,
Zidovudine

5

Which drugs fall under the category of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)

Delavirdine,
Efavirenz,
Etravirine,
Nevirapine

6

Which drugs are known as protease inhibitors?

ending in "navir"

7

Which drugs are entry inhibitors?

Enfuvirtide, Maraviroc

8

Which drugs are integrase inhibitors?

Raltegravir

9

Which NRTI is a thymidine analog?

Stavudine

10

What are special adverse effects of Zidovudine?

• Bone marrow suppression (neutropenia, anemia)

11

Which drug is a strong inhibitor of beta and gamma DNA polymerase?

Stavudine

12

What are AE of Stavudine?

• Peripheral neuropathy, lactic acidosis
• Hyperlipidemia, neuromuscular weakness

13

Which AE is unique to Didanosine?

• Pancreatitis (esp. alcoholics and patients with hypertriglyceridemia)

14

What is the Only NRTI with sig. drug interactions (increases didanosine concentrations and dosage reductions are
usually required)

Tenofovir

15

What is the most notable AE of Emtricitabine?

• Hyperpigmentation of palms and soles (occurs most frequently in dark-skinned people)