Flashcards in 11.0 Antiretrovirals Deck (15):
What are the 3 enzymes in HIV?
3) Reverse Transcriptase
What receptor in HIV is most important for binding?
When is therapy usually initiated for HIV?
-When CD4+ cells drop less than 500 cells/mm3
• History of an AIDS-defining illness
• HIV-associated nephropathy (HIVAN)
• HIV/hepatitis B virus (HBV) co-infection
Which drugs fall under the class Nucleoside/-tide Reverse Transcriptase Inhibitors (NRTIs)?
Which drugs fall under the category of Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)
Which drugs are known as protease inhibitors?
ending in "navir"
Which drugs are entry inhibitors?
Which drugs are integrase inhibitors?
Which NRTI is a thymidine analog?
What are special adverse effects of Zidovudine?
• Bone marrow suppression (neutropenia, anemia)
Which drug is a strong inhibitor of beta and gamma DNA polymerase?
What are AE of Stavudine?
• Peripheral neuropathy, lactic acidosis
• Hyperlipidemia, neuromuscular weakness
Which AE is unique to Didanosine?
• Pancreatitis (esp. alcoholics and patients with hypertriglyceridemia)
What is the Only NRTI with sig. drug interactions (increases didanosine concentrations and dosage reductions are