13.1 Anti-Malarials Flashcards Preview

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Flashcards in 13.1 Anti-Malarials Deck (6):
1

What are the clinical application of Malarone?

Treatment & prophylaxis of P. falciparum

2

What are the clinical applications of Inhibitors of Folate Synthesis?

• Chemoprophylaxis: only in combination. Proguanil +
chloroquine = no longer recommended

• Intermittent Preventive Therapy: high-risk patients
receive intermittent therapy regardless of infection status

• Treatment of chloroquine-resistant falciparum malaria
: pyrimethamine-sulfadoxine commonly used. DO NOT
use for severe malaria

3

Which antimalarial is active against erythocytic shizonts of all human malaria parasites? (not active against liver stage)

Doxycycline

4

What are the AE of Doxycycine?

• GI, candidal vaginitis, photosensitivity

• Discoloration & hypoplasia of teeth, stunting of
growth

• Fatal hepatotoxicity (in pregnancy)

• DO NOT use in pregnancy or children < 8y (FDA
Category D)

5

Which antimalarial class is derived from qinghaosu plant?

Atemisinin

6

What is the MOA of Artemisinin?

Appears to act by binding iron, breaking down peroxide
bridges leading to generation of free radicals that damage
parasite proteins.