Hypothalamic and Pituitary Hormones 1.1 Flashcards Preview

Pharmacology > Hypothalamic and Pituitary Hormones 1.1 > Flashcards

Flashcards in Hypothalamic and Pituitary Hormones 1.1 Deck (14):
1

MOA of Somatropin and Somatrem

Activates IGF-1 via JAK2/STAT signaling cascade

(effects mediated by IGF-1)

2

Indication of Somatropin and Somatrem (6)

1) GH deficiency
2) Short stature and adiposity in children
3) Hypoglycemia (unopposed insulin)
4) Growth failure assoc with Noonan, Prader-Willi or Turner syndrome in peds.
5) Wasting in HIV pts
6) Short bowl syndrome

3

Notable PK of Somatropin and Somatrem

CYP450 induction

4

AE of Somatropin and Somatrem in children: (7)

1) Hypothyroidism
2) Gynecomastia
3) Intracranial hypertension
4) Scoliosis
5) Pancreatitis
6) Otitis Media (Turner Syndrome)
7) Diabetic syndrome

5

AE of Somatropin and Somatrem in adults: (5)

1) Edema
2) Carpal Tunnel
3) Retinopathy
4) Myalgia
5) Arthralgia

6

Somatropin and Somatrem is contraindicated in whom?

Patient's with malignancy

7

GHRH analog

Sermorelin

8

MOA of Sermorelin?

Stimulates release of GH

9

AE of sermorelin?

Same as Somatropin

10

Fun fact about sermorelin?

Does not work in patients with defective anterior pituitary

11

Mecasermin is a?

IFG-1 analog

12

MOA of Mecasermin

Needs to be combined with IGF-1 binding protein 3 to see clinical effects

13

Indication of Mecasermin (3)

1) Growth failure due to decreased IGF-1
2) GH receptor mutation
3) Neutralizing anti-GH antibody

14

AE of Mecasermin (3)

1) Hypoglycemia
2) Intracranial HTN
3) Increased liver enzymes