15.1 Anticancer Flashcards Preview

Pharmacology > 15.1 Anticancer > Flashcards

Flashcards in 15.1 Anticancer Deck (12):
1

What drugs are given for Hodgkin's Lymphoma

–A-Adriamycin (Doxorubicin)
–B-Bleomycin
–V-Vincristine
–D-Dacarbazine

2

What anticancer drugs do not cause bone marrow suppression? (2)

1) Bleomycin
2) Vincristine

3

Which drugs are used for testicular cancer?

–B-Bleomycin
–E-Etoposide
–P-Platinum (Cisplatin)

4

What is adjuvant chemotherapy?

Chemotherapy is added in addition to surgery or radiotherapy

5

What is Neo-adjuvant chemotherapy?

Chemotherapy given before surgery to decrease the size of tumor.

6

What is induction chemotherapy?

chemotherapy given to obtain complete remission from the tumor, usually blood cancers.

7

What is maintenance chemotheraphy?

chemotherapy given to maintain remission from the cancer

8

Alkylation occurs where?

Alkylation at N7 position of guanine in DNA

9

Cyclophosphamide metabolims gives a toxic compound called what?

Acrolein

10

What inactivates acrolein?

MESNA

11

What is Ifosfamide?

•Mechanism of action & ADR similar to cyclophosphamide

•More potent than cyclophosphamide

•More potential to cause hemorrhagic cystitis

•Prior administration of MESNA is a must for each dose

12

Which alkylating agents cross the BBB?

Nitrosoureas

(highly lipophyllic)