Flashcards in 8.1 Antibacterials and Antimicrobials Deck (15):
What is the DOC for enterobacter infection and extended spectrum B-lactamase producing gram negatives?
(Imipenem & Meropenem)
Which carbapenem forms a potentially nephrotoxic metabolite, which can lead to seizures (high levels)
Which drug is given ONLY for gram negative aerobic rods? (including pseudomonas)
What is the best way of delivering Aztreonam for cystic fibrosis patients?
Which drug is active against gram positive only, and is effective against multi drug resistant organisms?
What is the mechanism of Vancomycin?
Binds D-Ala-D-Ala terminus of nascent peptidoglycan pentapeptide -> inhibition of cell wall synthesis & peptidoglycan polymerization
How does Vancomycin gain resistance?
Modication of the binding site: lactate replaces Ala
What drug does one give in combination with an aminoglycoside for empirical treatment of infective endocarditis?
How does one give Vancomycin for treatment of Staphylococcal enterocolitis or antibiotic associated C. Diff?
What are the adverse effects of Vancomycin? (3)
1) Red man syndrome (infusion related flushing over face and upper torso)
2) Ototoxicity (Drug accumulation)
3) Nephrotoxicity (drug accumulation) (esp with aminoglycoside combination)
Which drug is effective against V-RSA, and is effective only against other gram positive organisms?
Daptomycin is not effective against what?
Pneumonia (mucus produced inactivates)
What is the MOA of Daptomycin?
Bingd to cell membrane via calcium-dependent insertion of lipid tail, which results in depolarization of cell membrane with K+ efflux -> cell death
What is the pharmacokinetics of Daptomycin?