Local Anesthetics Flashcards Preview

Pharmacology > Local Anesthetics > Flashcards

Flashcards in Local Anesthetics Deck (33):
1

List the Benzylisoquinolines
non depols

atracurium
cisatracurium
cisatracurium
tubocurarine

2

List the ammonio steroids

nondepols

pancuronium
rocuronium
vecuronium

3

which nondepol is short acting?

mivacurium

4

which nondepol is intermediate acting

atracurium
cisatracurium
rocuronium
vecuronium

5

which nondepol is long acting

tubocuraraine
pancuronium

6

kidney excreted or liver excreted have longer half lives

kidney - longer
liver - shorter

7

Name elimination mechanism for short acting mevacrium

plasma pseudcholinesterase

8

Name elimiation for atracurium intermediate

enzymatic and non enzymatic --> laudanosine -- hypotension and seizures

9

Name elimination for intermediate cisatracurim

spontaneous and renal

10

name elimianation for intermediate rocuronium

hepatic 80% and renal

11

name elimination for vecuronium intermiediate

hepatic 80% and renal

12

name elimination for long pancuronium

renal 80% and hepatic

13

name elimination for long tubocurarine

renal and hepatic

14

i say laudanosine you think this nondepol and then you'd replace it with this nondepol

atracurium (hydrolyzed by non specific plasma esterase; not effected at renal failure) --< laudanosine can cause hypotension and seizures --> replace with cisatracurium that produces less laudanosine

15

how is mivacurium depol

only short acting

butyrylcholinesterase
not dependent on lvier or kidney

16

which is the most rapid onset?

rocuronium

17

a/se of benzylisoquinolines

hypotension bc they cause histamine release and ganglionic blockade

18

a/se of ammonio steroids

tachycardia due to blockade of muscarnic receptors - arrhtymias

19

i say histamine release and you think

benzyls

tubocurarine > mivacurium and atracurium

20

i say ganglion blockated and you think

tubocurarine = hypotension and tachycardia

21

i say blockade of cardiac M2 receptors and you think?

pancuronium - tachyca`rdia

22

a/se of depol blocker

stimulates nicotinic and muscarinic receptors
* bradycardia
*histamine release
* muscle pain
* hyperkalemia
*increased IOP
* increased intragastric pressure

23

who causese malignant hypertension and hwo do you treat it?

succinylcholine and haloperidol

tx with dan-tro-leenn

24

Spasmolytics MOA mania: diazepam

facilitates action of GABA at GABAa receptors

25

Spasmolytics MOA mania: baclofen

GABAb agonist

26

Spasmolytics MOA mania: tizanidine

alpha 2 agonist in CNS

27

Spasmolytics MOA mania: gabapentin

increases GABA release

28

Spasmolytics MOA mania: progabide

GABAa and GABAb agonist

29

Spasmolytics MOA mania: glycine

inhibitory aa neurotransmitter

30

Spasmolytics MOA mania: idrocilamide and rilouzole

ALS

inhibit glutaminergic

31

Spasmolytics MOA mania: dantrolene

malignant hyperthermia

prevents RYR from releasing Ca++

32

Spasmolytics MOA mania: botulinnum

cerebral palsy

33

cyclobenzaprine

muscle spasm from strain or truama