12.0 Antiparasitic Drugs Flashcards Preview

Pharmacology > 12.0 Antiparasitic Drugs > Flashcards

Flashcards in 12.0 Antiparasitic Drugs Deck (15):
1

Which are the mixed antiamebics?

Metronidazole
Tinidazole

2

What is the DOC for treating amebosiasis?

Metronidazole

3

What is the MOA of Metronidazole?

• Once absorbed, metronidazole is non-enzymatically
reduced by reacting with reduced ferredoxin

4

What are the most important AE from Metronidazole?

GI distress
Disulfiram-like rxn
Unpleasant metallic taste

5

What are the Luminal Antiamebics?

• Diloxanide furoate
• Iodoquinol
• Paromomycin

6

What are the systemic antiamebics?

• Chloroquine
• Emetine
• Dehydroemetine

7

Which drug class is useful for treating liver abscesses or intestinal wall infections?

Systemic Antiamebics

8

Which drugs are in the Benzimidazoles?

• Albendazole
• Mebendazole (most common)
• Thiabendazole

9

Mebendazole is the DOC for what?

• Whipworm (Trichuris trichiura)
• Pin worm (Enterobius vermicularis)
• Hookworms (Necator americanus &
Ancylostoma duodenale)
• Roundworm (Ascariasis lumbricoides)

10

Which benzimidazole is the most toxic?

Thiabendazole

11

What is the MOA of Ivermectin?

• GABA agonist
• Cl- influx increases leading to hyperpolarization of nerve /
muscle cell. Death occurs due to paralysis of parasite

12

Ivermectin in contraindicated in what?

Pregnancy
Meningitis
Avoid combination with other drugs that enhave GABAergic activity

13

Which drug has activity against Wuchereria bancrofti?

Doxycycline

14

What is Praziquantel the DOC for?

• of Drug choice for all forms of schistosomiasis & most trematode & cestode infections

15

What is the DOC for fasciolosis?

Bithionol