Flashcards in 12.0 Antiparasitic Drugs Deck (15):
Which are the mixed antiamebics?
What is the DOC for treating amebosiasis?
What is the MOA of Metronidazole?
• Once absorbed, metronidazole is non-enzymatically
reduced by reacting with reduced ferredoxin
What are the most important AE from Metronidazole?
Unpleasant metallic taste
What are the Luminal Antiamebics?
• Diloxanide furoate
What are the systemic antiamebics?
Which drug class is useful for treating liver abscesses or intestinal wall infections?
Which drugs are in the Benzimidazoles?
• Mebendazole (most common)
Mebendazole is the DOC for what?
• Whipworm (Trichuris trichiura)
• Pin worm (Enterobius vermicularis)
• Hookworms (Necator americanus &
• Roundworm (Ascariasis lumbricoides)
Which benzimidazole is the most toxic?
What is the MOA of Ivermectin?
• GABA agonist
• Cl- influx increases leading to hyperpolarization of nerve /
muscle cell. Death occurs due to paralysis of parasite
Ivermectin in contraindicated in what?
Avoid combination with other drugs that enhave GABAergic activity
Which drug has activity against Wuchereria bancrofti?
What is Praziquantel the DOC for?
• of Drug choice for all forms of schistosomiasis & most trematode & cestode infections