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Flashcards in 8.2 Deck (11)
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1
Q

What bacteria is bacitracin indicated for?

A

Gram + only

2
Q

What enzyme does Fosfomycin inhibit?

A

Enol-pyruvate transferase

3
Q

What are the drugs in the class tetracyclines?

A

1) Doxycycline
2) Minocycline
3) Tetracycline

4
Q

How do tetracyclines get into the cell?

A

Passive diffusion and energy dependent transport unique to bacterial inner cytoplasmic membrane

5
Q

What is the MOA of tetracyclines?

A

Binds reversibly to 30 s subunit of ribosome

6
Q

What are the 3 main mechanisms by which Tetracyclines gain resistance?

A
  • Impaired influx or increased efflux by active protein pump
  • Production of proteins that interfere with binding to ribosome
  • Enzymatic inactivation
7
Q

What is the most common use of tetracyclines?

A

Severe acne and rosacea

8
Q

If someone has a penecillin allergy, what can be given to a patient with syphillis?

A

Tetracycline

9
Q

Tetracyclines can be used in combination for? (3)

A
  • H.pylori eradication
  • Malaria prophylaxis and treatment
  • Treatment of plague, tularemia, brucellosis
10
Q

Where does tetracycline concentrate? (4)

A

Kidney
Liver
Spleen
Skin

11
Q

Can tetracyclines be given in pregnancy?

A
  • NO. They are teratogenic. All cross placenta and are excreted into breast milk.
  • Category D.