Flashcards in 8.2 Deck (11):
What bacteria is bacitracin indicated for?
Gram + only
What enzyme does Fosfomycin inhibit?
What are the drugs in the class tetracyclines?
How do tetracyclines get into the cell?
Passive diffusion and energy dependent transport unique to bacterial inner cytoplasmic membrane
What is the MOA of tetracyclines?
Binds reversibly to 30 s subunit of ribosome
What are the 3 main mechanisms by which Tetracyclines gain resistance?
• Impaired influx or increased efflux by active protein pump
• Production of proteins that interfere with binding to ribosome
• Enzymatic inactivation
What is the most common use of tetracyclines?
Severe acne and rosacea
If someone has a penecillin allergy, what can be given to a patient with syphillis?
Tetracyclines can be used in combination for? (3)
• H.pylori eradication
• Malaria prophylaxis and treatment
• Treatment of plague, tularemia, brucellosis
Where does tetracycline concentrate? (4)