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Flashcards in 8.2 Deck (11):
1

What bacteria is bacitracin indicated for?

Gram + only

2

What enzyme does Fosfomycin inhibit?

Enol-pyruvate transferase

3

What are the drugs in the class tetracyclines?

1) Doxycycline
2) Minocycline
3) Tetracycline

4

How do tetracyclines get into the cell?

Passive diffusion and energy dependent transport unique to bacterial inner cytoplasmic membrane

5

What is the MOA of tetracyclines?

Binds reversibly to 30 s subunit of ribosome

6

What are the 3 main mechanisms by which Tetracyclines gain resistance?

• Impaired influx or increased efflux by active protein pump
• Production of proteins that interfere with binding to ribosome
• Enzymatic inactivation

7

What is the most common use of tetracyclines?

Severe acne and rosacea

8

If someone has a penecillin allergy, what can be given to a patient with syphillis?

Tetracycline

9

Tetracyclines can be used in combination for? (3)

• H.pylori eradication
• Malaria prophylaxis and treatment
• Treatment of plague, tularemia, brucellosis

10

Where does tetracycline concentrate? (4)

Kidney
Liver
Spleen
Skin

11

Can tetracyclines be given in pregnancy?

- NO. They are teratogenic. All cross placenta and are excreted into breast milk.
- Category D.