Hypothalamic and Pituitary Hormones 1.2 Flashcards Preview

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Flashcards in Hypothalamic and Pituitary Hormones 1.2 Deck (15):
1

GH receptor antagonist

Pegvisomant

2

MOA of pegvisomant

Prevents dimerization

3

Indication of Pegvisomant

Small GH secreting tumor

4

Octreotide action is mediated by?

Disulfide bridge between cysteine residues

5

MOA of Octreotide?

Inhibits release of GH, glucagon , insulin and gastrin

6

Indication of Octreotide?

1) Reduce symptoms of hormone secreting tumors (acromegaly, carcinoid, gastrinoma etc)
2) Localize neuroendocrine tumors
3) Control variceal bleeding

7

AE of Octreotide (7)

1) Nausea and Vomiting
2) Steatorrhea
3) Constipation
4) Gallstones
5) Pain at injection sites
6) Sinus bracycardi
7) B12 Deficiency

8

Bromocriptine
Cabergoline

-Dopamine agonist

-Inhibit prolactin and GH secretion.

9

MOA of Bromocriptine & Cabergoline

Activates post synaptic dopamine receptors

10

Indication of Bromocriptine & Cabergoline (2)

1) Prolactinoma
2) Acromegaly (in combination with surgery, radiation or octreotide)

11

Half life of Cabergoline

65 hours

12

Half life of Bromocriptine

7 hours

13

AE of Bromocriptine/Cabergoline

1) Nausea, Headache, Lightheadedness
2) Orthostatic hypotension, fatigue
3) Psych manifestations
4) High dose leads to cold induced peripheral vasospasms
5) Pulmonary infiltrates

14

Menotropins

Purified FSH & LH

15

Purified FSH

Follitropin
Urofollitropin