11.2 Antiretrovirals Flashcards Preview

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Flashcards in 11.2 Antiretrovirals Deck (12):
1

Which Protease Inhibitor is an enhancer or booster of other PI's due to inhibition of CYP3A4?

Ritonavir

2

Which Protrease Inhibitor is structurally unrelated to other PI's?

Atazanavir

3

How is Atazanavir metabolized?

Metabolized by and inhibits CYP3A4

4

Which antiretroviral drug binds integrase?

Raltegravir

5

What are current recommendations for treatment-naive patients?

(1) NNRTI & 2 x NRTI

(2) PI (preferably boosted with ritonavir) & 2 x NRTI

(3) INSTI & 2 x NRTI

6

What is the NNRTI based regimen?

Efavirenz + tenofovir + emtricitabine

7

What is the PI based regimen?

(1) Ritonavir-boosted atazanavir + tenofovir + emtricitabine
(2) Ritonavir-boosted darunavir + tenofovir + emtricitabine

8

What is the INSTI based regimen?

Raltegravir + tenofovir + emtricitabine

9

What is the current recommendation for pregnant patients?

Ritonavir-boosted lopinavir (twice daily) +
zidovudine/lamivudine

10

What is the current recommendation for infant born to HIV infected mother?

Zidovudine (start immediately after birth and administer for 6 weeks)

11

What is the preferred regimen for healthcare personnel upon exposure to HIV?

Raltegravir + tenofovir + emtricitabine

12

Which prophylactic vaccines are recommended for HIV patients?

• Streptococcus pneumoniae
• Hepatitis A
• Hepatitis B and
• Influenza