2 NSAIDs Flashcards Preview

Pharmacology > 2 NSAIDs > Flashcards

Flashcards in 2 NSAIDs Deck (29):
1

Using NSADs causes damage to gastric barrier how?

Inhibition of COX-1

2

COX-2 is constitutive where?

Kidney and Brain

3

What is the primary source of vascular prostacyclin?

Endothelial COX-2

4

Idomethacin use?

Gout

5

All NSAIDs can be used to treat gout except which ones?

Aspirin
Salicyclates
Tolmetin

6

Why is not aspirin used for gout?

- It inhibits urate excretion at low doses
- May increase risk of renal calculi at high doses

7

Tolmetin is ineffective for which arthritis?

Gout

8

Frequent use of aspirin is associated with a 50% DECREASE in the risk of what?

Colon Cancer

9

Niacin flushing is mediated by what?

Release of PGD2

10

Niacin flushing can be inhibited with what?

Aspirin

11

What is the DOC for closure of ductus arteriosus?

Indomethacin

12

What are the two mechanisms by which NSAIDs cause gastric damage?

1) Inhibition of COX-1 in gastric epithelial cells
2) Ulceration by local irritation of the gastric mucosa

13

Which drugs reduce the rick of gastric ulcer and are used in the treatment of gastric damage induced by NSAIDs

1) Misoprostol
2) PPI
3) H2 blockers

14

Which NSAID has the lowest risk of adverse GI effects?

Celecoxib

15

Which NSAIDs (3) are low risk for GI adverse effects?

1) Ibuprofen
2) Aspirin
3) Diclofenac

16

Which NSAIDs (2) are medium risk for GI adverse effects?

1) Naproxen
2) Indomethacin

17

Which NSAID has the highest risk for adverse GI effects

Piroxicam

18

How do NSAIDs cause adverse cardiovascular effects

Thought to be caused by NSAIDs upsetting the balance between TXA2 and PGI2

19

What are the cardiovascular effects of NSAIDs?

1) Vasocontriction
2) Platelet aggregation
3) Thrombosis

20

Which NSAIDs have more CV risk?

More COX-2 selective

21

What is the only selective COX-2 inhibitor in the US?

Celecoxib

22

How do NSAIDs affect the renal system? (3)

1) Decrease in Renal Blood Flow
2) Acute interstitial Nephritis
3) Analgesic Nephropahty

23

Why is Aspirin unique?

It IRREVERSIBLY acetylates COX

24

How does a low dose of aspirin affect platelets?

Production of PGI2 is relatively unaffected

25

What happens when a person is given 1g or more of aspirin?

-Conjugation enzymes become saturated and zero-order kinetics are observed

26

Why is not Acetaminophen not an NSAID?

Because it has no anti-inflammatory or antiplatelet effect

27

What is the DOC for pain relief in osteoarthritis

Acetaminophen

28

What is the DOC for short-term treatment of fever and minor pain during pregnancy

Acetaminophen

29

What is the DOC for short-term treatment of fever and flulike symptoms

Acetaminophen