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Flashcards in 8.5 Deck (15):
1

What is the MOA of Clindamycin?

Reversible binding of 50S subunit

2

What is a good alternative to a person who does not respond to co-trimoxazol for PCP

Clindamycin + Primaquine

3

What is the most important adverse effect of Clindamycin?

Potentially fatal pseudomembranous colitis (C.Diff)

4

What is Clindamycin mostly used for?

mainly Gram + anaerobes including bacteroides

5

How does Clindamycin gain resistance?

Due to:
• mutation of ribosomal receptor site
• modification of the receptor
• enzymatic inactivation of drug

• Most Gram-negative aerobes & enterococci are intrinsically resistant

• Cross-resistant with macrolides

6

Which drugs are considered Streptogramins?

1) Quinupristin
2) Dalfopristin

7

What is the MOA of Streptogramins?

Bind to separate sites on 50S becterial ribosome

8

What is the clinical application of Streptogramins?

• Restricted to treatment of infections caused by drugresistant
Staphylococci or VRE

9

Which cytochrome does Streptogramins inhibit?

CYP 3A4

10

What is the MOA of Linezolid?

• Inhibits formation of 70S initiation complex

• Binds to unique site on 23S ribosomal RNA of 50S subunit

11

What is important to rmbr about the PK of Linezolid?

- Oral & IV
- Weak reversible inhibitor of MAO

12

What are the contraindications of Linezolid?

• Reversible, nonselective inhibitor of MAO -> potential
to interact with adrenergic and serotonergic drugs

13

What is the use of Fidazomicin?

• Activity against Gram-positive aerobes and
anaerobes especially Clostridia

14

What is the MOA of Fidaxomicin?

• Inhibits bacterial protein synthesis by binding to RNA
polymerase

15

What is the benefit of Fidaxomicin?

Recurrence of C.Diff is greatly reduced