Flashcards in 8.5 Deck (15):
What is the MOA of Clindamycin?
Reversible binding of 50S subunit
What is a good alternative to a person who does not respond to co-trimoxazol for PCP
Clindamycin + Primaquine
What is the most important adverse effect of Clindamycin?
Potentially fatal pseudomembranous colitis (C.Diff)
What is Clindamycin mostly used for?
mainly Gram + anaerobes including bacteroides
How does Clindamycin gain resistance?
• mutation of ribosomal receptor site
• modification of the receptor
• enzymatic inactivation of drug
• Most Gram-negative aerobes & enterococci are intrinsically resistant
• Cross-resistant with macrolides
Which drugs are considered Streptogramins?
What is the MOA of Streptogramins?
Bind to separate sites on 50S becterial ribosome
What is the clinical application of Streptogramins?
• Restricted to treatment of infections caused by drugresistant
Staphylococci or VRE
Which cytochrome does Streptogramins inhibit?
What is the MOA of Linezolid?
• Inhibits formation of 70S initiation complex
• Binds to unique site on 23S ribosomal RNA of 50S subunit
What is important to rmbr about the PK of Linezolid?
- Oral & IV
- Weak reversible inhibitor of MAO
What are the contraindications of Linezolid?
• Reversible, nonselective inhibitor of MAO -> potential
to interact with adrenergic and serotonergic drugs
What is the use of Fidazomicin?
• Activity against Gram-positive aerobes and
anaerobes especially Clostridia
What is the MOA of Fidaxomicin?
• Inhibits bacterial protein synthesis by binding to RNA