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Flashcards in Anti-psychotics Deck (30):
1

SHARK: grouped concepts
~ notes have in bold
* i think will be high yield

hurah

2

concept: cause of positive psychotic symptoms and goal of how we wnat to treat them

increased dopamine in the mesolimbic system; we want to treat them by DECREASING DA effects -> block D2 receptors

3

concept to understand s/e of treatment: Describe the mesolimbic pathway

midbrain to limbic system = emotional behavoiurs

hyperactivity = positive psychotic symptoms
**block D2 here to stope psychosis

4

concept to understand s/e of treatment: nigrostriatal pathway

substantia nigra to basal nigra = motor movements

when block D2 here - extrapyramidla reactiosn = funy motor movemetns like parkinson disease and such

5

concept to understand s/e of treatment: mesocortical pathway

midbrain to prefrontal cortex = if reduced activity then have negative and cognitive symptoms

if block D2 here get worse cognitive and negative symptoms

6

concept to understand s/e of treatment: tuberoinfundibular pathway

hypothalamus to anterior pituitar = DA inhibits prolactin

block D2 - prolactinema = galacthorrhoea

7

Name the CLASSIC antipsychotics
CFHT
-AZINEs

chlorpromAZINE
fluphenAZINE
haloperidol
thioridAZINE

8

Name the ATYPICAL antipsychotics
CROQ-ZAP
-PINE
-DONE
and randoms

clozaPINE
risperiSONE
olanzaPINE/aux-lanse epine
quetiaPINE
ziprasiDONE
aripiprazole
paliperiDONE

aka if a word looks like you are having a hallucination assume its a this

9

Name the high potency classic antipsychotics ie the ones who will cause the most extrapyramidal reactions (inhibition of the nigrostrial pathway)

C
FluphenAZINE
Haloperidol
T

10

Name the low potency classic antipsychoticsc ie the drugs that will cause the least extrapyramidal reactions (lower inhibition of the nigrostiatal pathway)

ChlopramAZINE
F
H
ThioridAZINE

11

Which classic antipsychotics are more likely to cause sedation and postural hypotension

the low potency drugs
ChlorpramAZINE
F
H
ThioridAZINE

12

Describe receptors affected by ClozAPINE

atypical antipsychotic CROQ-ZAP
* high affinity for D1, D4, D4, 5HT2, muscarinic and alpha adrenergic
PROTOTYPE

13

~*~Special facts about Resperidone

5HT2 blockage more than D2

MOST LIKELY TO CAUSE EPR

14

Atypical antipsychotics least likely to cause EPR

ClozAPINE
R
O
QuetiAPINE
Z
A
P

15

Describe receptors affected by Aripiprazole

partial agonist at D2 and5HT1a
antagonist at 5HT2a

16

Compare and contrast side effects of atypical to typical antipsychotics

atypicals less likely to cause a) EPR, b) tardive dyskinesia c) increases in prolactin d) better at treating negative symptoms
:)

17

Only antipsychotics to not cause anti-emetic side effects

C
F
H
Thioidazine

C
R
O
Q
Z
Apriprazole
P

18

Why do chlorpromazine and thioridazine show less EPR than haloperidol and thioridizine

because chlorpromazine an dthioridazine have increased anticholinergic effects

19

What will cause ''parkinsonism'' and how will you treat it?

calssic antipsychotics C, Fluphenazine, Haloperidol, T

treat with anti muscarnics:
a) benztropines
b) trihyxyphenidyle
c) diphenhydramine
d) amantadine

20

What will you treat DYSTONIA with?

a) benztropine
b) trihexyphenidyl
c) diphenhydramine

21

What will you treat AKATHISIA with?

clonazepam
propanolol

22

How will you treat someone who needs antipsychotics but has tardive dyskinesia?

a) discontinue antipsychotic
b) eliminate central anticholinergics (TCA nacid, antiparkinsonina drugs)
c) diazepam
d) release antipsychotic with CLOZAPINE

23

Name drugs more likely to cause sedation used for anti psychotic treatment

CROQ ZAP
C: clozapine
R: respiridone
O: olanzapine
Z: ziprasidone
A: airiprazole
P: popilperidone... or something like that

24

Name antipsychotics most likely to cause seizures

Cs for seizure
chlorpromaizine = classic
clozapine - atypiocal

25

Describe symptoms of Neuroleptic Malignant Syndomre. How to treat?

ridigity, tremor, hyperthermia

altered mental status

autonomic instability

elevated wbc and CK

myoglobinemia with potentail nephrotoxicity

DANTROLENE or BROMOCRIPTINE

26

What do you have to watch out for with clozapine

agranulocytosis

check WBC regularly

(Acarbose @ diabetes check LFT)

27

Two antipsychotics that can have effects on the heart

Thioridazine (less EPR, more anticholinergic) = QTc and T wave changes -- ventricular arrhythmias and sudden death
Ziparsidone can also prolong QTc

28

What two antipsychotics can produce ocular complications and esplain them please

Chlorpromaizine - deposits in cornea and lens

Thioridazine - retinal deposits

29

Who cares about Droperidol

people who need neurolept anesthesia with nausea and vomiting - treat in combo with fentanyl

30

what antipsychotic is prescribed the most in the USA

resperidone - causes EPR but rare at therapeutic doses