Flashcards in Pharm small group: HIV 3 Deck (9):
What is the DOC for PCP?
What is the MOA of trimethoprim?
Reversibly inhibits dihydrofolate reductase
What is the MOA of sulfamethoxazole?
competitively inhibits dihydropteroate synthase
What does dihydropteroate synthase do?
incorporates PABA into dihydropteroic acid, the immediate precursor of folic acid
Trimethoprim exerts a synergistic effect with what?
High dose therapy with TMP-SMX can lead to what skin adverse effects?
1) Erythematou, maculopapular, morbilliform rash
2) severe urticaria
3) Exfoliative dermatitis
4) Steven Johnson Syndrome
What are the hemotological side effects of TMP-SMX toxicity?
What is a common AE with TMP-SMX toxicity
GI (N/V abdominal pain)