Pharm small group: HIV 3 Flashcards Preview

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Flashcards in Pharm small group: HIV 3 Deck (9):
1

What is the DOC for PCP?

TMP-SMX

2

What is the MOA of trimethoprim?

Reversibly inhibits dihydrofolate reductase

3

What is the MOA of sulfamethoxazole?

competitively inhibits dihydropteroate synthase

4

What does dihydropteroate synthase do?

incorporates PABA into dihydropteroic acid, the immediate precursor of folic acid

5

Trimethoprim exerts a synergistic effect with what?

Sulfanomides

6

High dose therapy with TMP-SMX can lead to what skin adverse effects?

1) Erythematou, maculopapular, morbilliform rash
2) severe urticaria
3) Exfoliative dermatitis
4) Steven Johnson Syndrome

7

What are the hemotological side effects of TMP-SMX toxicity?

1) Leukopenia
2) Anemia
3) Thrombocytopenia

8

What is a common AE with TMP-SMX toxicity

GI (N/V abdominal pain)

9

What adjunctive corticosteroid therapy is given in patients with moderate-severe PCP? (p02 <70)

Oral Prednisone or IV Methylprednisone