Acute Leukaemia Flashcards Preview

Clinical Pathology > Acute Leukaemia > Flashcards

Flashcards in Acute Leukaemia Deck (30):
1

Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues

Acute leukaemia

2

Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues

Acute leukaemia

3

2 major groups of acute leukaemia

Acute lymphoblastic leukaemia
Acute myeloid leukaemia

4

Hamatopoietic blast cells constitute what proportion of the bone marrow?

>20%

5

Clinical features of acute leukaemia

Features of bone marrow failure:
anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses

6

Give 2 examples of infections you might get in acute leukaemia

Staph A infection of orbit
Perianal infection with strep. faecalis, E.coli or oral candida

7

Why do you get ecchymoses in acute leukaemia

Thrombocytopenia

8

What is the difference between primary and secondary AML

Secondary AML follows previous myeloproliferative or myelodysplastic disease

9

What age group does AML affect?

All ages

10

Prognosis of AML

30-50% 15-55yrs

11

Type of acute leukaemia resulting from a chromosomal transolation in utero

ALL

12

Most common malignancy in childhood

AML

13

Prognosis of AML in childhood

80% cured

14

Lab features of acute leukaemia

Anaemia
Neutropenia
Thrombocytopenia

15

Lab features of acute leukaemia

Anaemia
Neutropenia
Thrombocytopenia

16

2 major groups of acute leukaemia

Acute lymphoblastic leukaemia
Acute myeloid leukaemia

17

Hamatopoietic blast cells constitute what proportion of the bone marrow?

>20%

18

Clinical features of acute leukaemia

Features of bone marrow failure:
anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses

19

Give 2 examples of infections you might get in acute leukaemia

Staph A infection of orbit
Perianal infection with strep. faecalis, E.coli or oral candida

20

Why do you get ecchymoses in acute leukaemia

Thrombocytopenia

21

What is the difference between primary and secondary AML

Secondary AML follows previous myeloproliferative or myelodysplastic disease

22

What age group does AML affect?

All ages

23

Prognosis of AML

30-50% 15-55yrs

24

Type of acute leukaemia resulting from a chromosomal transolation in utero

ALL

25

Most common malignancy in childhood

AML

26

Prognosis of AML in childhood

80% cured

27

4 major clinical features of acute leukaemia

28

Lab features of acute leukaemia

Anaemia
Neutropenia
Thrombocytopenia

29

Define neutropenic fever

Pyrexia in the presence of a neutrophil count

30

Treatment of neutropenic fever

Broad spectrum IV antibiotics within 30 mins of temperature- tazocin or gentamicin