Flashcards in Acute Leukaemia Deck (30):
1
Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues
Acute leukaemia
2
Accumulation of early myeloid or lymphoid precursors in the bone marrow, blood and other tissues
Acute leukaemia
3
2 major groups of acute leukaemia
Acute lymphoblastic leukaemia
Acute myeloid leukaemia
4
Hamatopoietic blast cells constitute what proportion of the bone marrow?
>20%
5
Clinical features of acute leukaemia
Features of bone marrow failure:
anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses
6
Give 2 examples of infections you might get in acute leukaemia
Staph A infection of orbit
Perianal infection with strep. faecalis, E.coli or oral candida
7
Why do you get ecchymoses in acute leukaemia
Thrombocytopenia
8
What is the difference between primary and secondary AML
Secondary AML follows previous myeloproliferative or myelodysplastic disease
9
What age group does AML affect?
All ages
10
Prognosis of AML
30-50% 15-55yrs
11
Type of acute leukaemia resulting from a chromosomal transolation in utero
ALL
12
Most common malignancy in childhood
AML
13
Prognosis of AML in childhood
80% cured
14
Lab features of acute leukaemia
Anaemia
Neutropenia
Thrombocytopenia
15
Lab features of acute leukaemia
Anaemia
Neutropenia
Thrombocytopenia
16
2 major groups of acute leukaemia
Acute lymphoblastic leukaemia
Acute myeloid leukaemia
17
Hamatopoietic blast cells constitute what proportion of the bone marrow?
>20%
18
Clinical features of acute leukaemia
Features of bone marrow failure:
anaemia, infections, early bruising or haemorrhage, organ infiltration by leukaemic cells, ecchymoses
19
Give 2 examples of infections you might get in acute leukaemia
Staph A infection of orbit
Perianal infection with strep. faecalis, E.coli or oral candida
20
Why do you get ecchymoses in acute leukaemia
Thrombocytopenia
21
What is the difference between primary and secondary AML
Secondary AML follows previous myeloproliferative or myelodysplastic disease
22
What age group does AML affect?
All ages
23
Prognosis of AML
30-50% 15-55yrs
24
Type of acute leukaemia resulting from a chromosomal transolation in utero
ALL
25
Most common malignancy in childhood
AML
26
Prognosis of AML in childhood
80% cured
27
4 major clinical features of acute leukaemia
28
Lab features of acute leukaemia
Anaemia
Neutropenia
Thrombocytopenia
29
Define neutropenic fever
Pyrexia in the presence of a neutrophil count
30