Flashcards in Nutritional Support in Trauma Deck (53)
What are the 3 phases of trauma
1. Clinical Shock
3.Recovery- anabolic state
When does phase 1: shock occur and how long does it last for?
2-6 hrs after injury. Lasts 24-48hrs
What chemical modulators are released into the blood in phase 1: shock
Cytokines, catecholamines, cortisol
4 clinical effects of phase 1: shock
Increased resp. rate
Aims during phase 1
When does phase 2 present
2 days after injury
What chemical modulators are released into the blood during phase 2
Catecholamines, glucagon, ACTH
4 clinical effects of phase 2
Increase in O2 consumption
Increase in metabolic rate
Increase in glycolysis
Increase in lipolysis
When does phase 3 present
Coincides with beginning of diuresis and requenst for oral intake. May not occur for weeks after severe trauma and sepsis
What is the obestiy paradox
Obesity is survival advantage in the recovery of trauma
What are the 3 cytokines that play the biggest roles after trauma
IL-1, IL-6 and TNF
What endocrine effects to cytokines have, after trauma
Cytokine mediated secretion of catabolic hormones (increase in ACTH, glucagon, catecholamines)
Cytokine mediated inhibition of anabolic hormones (less growth hormone, less insulin)
How many grams of glucose/day/kg does the brain require?
What does the brain use as an energy substrate when glucose is not available?
How do the kidneys and liver adapt to less glucose availibility?
What substrates does the liver and kidney use for gluconeogenesis?
Fatty acids/amino acids
What substrates does skeletal muscle use for gluconeogenesis?
Glycogen stores/amino acids
What are the 3 main metabolic responses to trauma, i.e. what happens when the supply of glucose and oxygen is interrupted?
Lipolysis and ketogenesis
How are lipids used to make ketones simultaneously?
What are the cellular effects of anaerobic respiration
Loss of membrane Na/K pump>cellular swelling and loss of membrane integrity>lysosomal enzyme release
What pH, H+conc. and lactate conc. is considered lactic acidosis
What are the 2 main metabolic effects of anaerobic respiration, and how do they come about?
Metabolic failure (inadequate energy production)
Metabolic acidosis (lactic acid production)
What are the effects of trauma on levels of:
free amino acids
ammonia conc. in plasma
Inflammatory modulators increase
free amino acids increase
Ammonia concentration in plasma increases
Nitrogen loss increases
What is the difference in administering adequate calories in patients who are starving and in trauma/sepsis patients?
In starvation, this will reverse muscle wasting. This is not true for trauma/sepsis patients
Why does providing calories not reverse muscle wasting in trauma/septic patients?
Because primary stimulation for protein breakdown is cytokine secretion from activated macrophages
What concentration of lactate in the blood has a 100% mortality?
At what time after trauma does N2 losses peak?
Protein calorie undernutrition (starvation)
Nutrients present in adequate amounts by appetite is suppressed, or absorption and utilization are inadequate or increased demand for specific nutrients to meet physiological needs