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Clinical Pathology > Skin and Soft Tissue Pathology > Flashcards

Skin and Soft Tissue Pathology Flashcards

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1
Q

4 commensal skin flora

A

Coagulase -ve staphylococci
Staph A
Proprionibacterium-acne
Corynebacterium

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2
Q

5 common commensal skin viruses

A 
Herpes viruses (HSV, VZV)
Moluscum contagiosum
HPV
Orf
Cowpox
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3
Q

Which virus is transmitted from sheep and results in ulcerative skin lesions

A

Orf

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4
Q

HZV pathogenesis

A

Vesicle forms which grows to form an ulcer. When it ruptures, it releases vesicle fluid containing infectious particles. Virus gains entry via sensory nerve endings and migrates along the nerve to the DRG where it remains latent and the immune response is not stimulated. When reactivated, the virus migrates outwards to sensory nerve endings and causes the clinical manifestations of infection- preceded by tingling

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5
Q

Triggers of reactivation of HSV

A

Infection or stress

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6
Q

Primary infections of HSV

A

Extensive, painful lesion, occurs only once. Rare. Normally HSV1. HSV2 is usually genital herpes.

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7
Q

Secondary infections fo HSV

A

All ages, recurrent infection. Peri-oral. Weeping, vesicular

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8
Q

Diagnosis of HSV

A

Clinical

Vesicle fluid contains virus-PCR

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9
Q

Treatment for HSV

A

Cold sores- topical aciclovir

Genical herpes/immunocompromised- oral aciclovir

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10
Q

Another name for strep pyogenes

A

Beta haemolytic streptococci

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11
Q

Usual causative organisms for bacterial skin infections

A

Staph A
Strep P
H. Influenzae
Pasteurella mulficida (grow in cat and dog’s mouths)

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12
Q

Gram +ve cocci in clusters. Catalase +ve. Normal nasal flora in 30% population

A

Staph A

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13
Q

Name some virulence factors of Staph A

A

DNAase
Coagulase
Teichoic acid
Exotoxin production e.g. epidemolytic toxins A & B, toxic shock syndrome toxin, PVL-boils

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14
Q

Really nasty bacteria, gram +ve cocci in chains. Catalase -ve.

A

Strep Pyogenes

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15
Q

Name some virulence factors of strep P

A 
Adhesins
M. proteins (antiphagocytic)
Streptolysins O and S
Hyaluronic capsule (antiphagocytic)
Hyaluronidase (facilitates intestinal spread)
C5a peptidase (anticomplementary)
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16
Q

Describe the rash in VZV

A

Weepeing, vesicular rash

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17
Q

Treatment for VZV

A

Oral aciclovir//valaciclovir

IV aciclovir if older, lower immune system or increased susceptibility to shingles

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18
Q

Causative organism for molluscum contagiosum

A

Molluscum contagiosum virus-poxvirus

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19
Q

Describe the appearance of molluscum contagiosum

A

Raised pearly lesions, umbilicated (central depressions) No sequelae.

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20
Q

Treatment of molluscum contagiosum

A

None. Usually disappear within 6-18 months. Physical treatments some times appropriate if disfiguring.

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21
Q

Causative organism for Impetigo

A

S. Aureus/S.Pyogenes

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22
Q

Often occurs at site of skin damage, superficial, thick scabs-‘honey crusted lesions’, with yellow exudate. often around the nose.

23
Q

Local manifestation of impetigo

Study These Flashcards
A

Bullous impetigo

24
Q

Generalised manifestation of impetigo

Study These Flashcards
A

Staph scalded skin syndrome

25
Pathogenesis of impetigo
Desmosermal glycoprotein desmoglein-1 which is requied for cell to cell adhesion in the superficial epidermis is inactivated by ETA and ETB (epidermolytic toxin)
26
Causative organism for erysipelas
S. pyogenes
27
Erysipelas
Infection of dermis Ocurs at site of skin damag, often face or shin. Preceded by pain and tenderness, well demarcated inflamed lesions-red, swollen, painful or hot. Fever, malaise and local lyphadenopathy.
28
Cellulitis
Infection of skin and subcutanous tissues, not bilateral.
29
Causative organisms of cellulitis
S. aureus S. pyogenes Pasteurella multicida (animal bites) H. influenza
30
What bacteria might give rise to peri-orbital cellulitis?
H. influenza
31
Causative organism for anthrax
Bacillus anthracis-spore forming aerobic gram +ve bacillus, acquired from imported animal hides or wool.
32
Describe the skin lesions in anthrax
Malignant pustular-eschar- dry dark scab | may develop into septicaemia
33
Risk factors for anthrax
Drum skin exposure | Injecting drug users
34
Describe the different types of anthrax
Cutaneous anthrax-readily treated | Inhalation/septicaemic antrhax-high mortality
35
Necrotising fasciitis
Infection of the skin and SC tissue. Spontaneous or at site of skin penetration. Any part of the body. Dark, rapidly spreading, necrotic lesion. Fever and malaise.
36
Describe the 2 types of Necrotising fasciitis
Type 1: polymicrobial - enteric gram -ve bacilli and anaerobes i.e. normal bowel flora. Type 2: strep pyogenes- acquired.
37
Another word for perineal necrotising fasciitis
Fournier's or syndergistic gangrene
38
Diagnosis of necrotising fasciitis
Blood or debrided material
39
Treatment for necrotising fasciitis
IV-antibiotics | or surgical debridement
40
Anaerobic Infections
Uncommon-ready availibility of O2. | Gas gangrene- similar to NF but with a palpable SC gas. Usually post operative at the site of surgery.
41
Common causative organism of gas gangrene
Clostridium perfringens
42
Treatment of gas gangrene
IV antibiotics | Surgical debridement
43
Treatment for impetigo (causative organism staph A)
Fusidic acid or mopirocen
44
Empiric bacterial skin infection treatment for those with a penicillin allergy
Erythromycin/clarithromycin/vancomycin/linezolid
45
Treatment for NF
Need to cover anaerobic bacteria so meropenem and clindamycin. Metronidazole is an anti-anaerobic agent.
46
Dermatophyte
Superficial fungal infection
47
Skin fungal infection
Tinea corporis, tinea pedis (athlete's foot)
48
Nail fungal infections
Onychomycosis
49
Scalp infections
Tinea capitis (scalp ringworm)
50
Describe Pityriasis Versicolour
What I have on my back- hypopigmented patches that come out in the summer- fungal infection
51
Causative organsims for dermatophyte infections
Tricophytum e.g T. rubum- circulates among humans | Microsporum- e.g. M.canis- circulates among animals
52
What level of the skin do you usually get dermatophyte infections?
Usually restricted to stratum corneum- rarely penetrate the lining cells of the epidermis. Use keratin as a nutritional substrate
53
Topical antifungal therapy
Clotrimazole | Terbinafine
54
Scalp and nale infections- systemic antifungal therapy
Terbinafine, itraconazole, friseofluin

Clinical Pathology (53 decks)

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