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Flashcards in Lymphoma and Myeloma Deck (23):
1

4 chronic causes of lymphadenopathy that affect the lymphoid lineage

Chronic lymphocytic leukaemia
Non Hodgkin Lymphoma
Hodgkin lymphoma
Multiple myeloma

2

Enlarged lymph nodes

Lymphadenopathy

3

3 common causes of lymphadenopathy

Infection
Autoimmune disease - SLE, HIV
Malignancy

4

Clonal neoplastic proliferation of lymphoid cells. Arise in the lymph nodes or lymphoid tissue

Lymphomas

5

2 types of lymphomas

Hodgkin lymphoma
Non-hodgkin lymphoma

6

Reed sternberge cells are associated with which type of lymphoma?

Hodgkin

7

Males are more commonly affected than females in which type of lymphoma

Hodgkin (the man, non-hodgkin the woman)

8

EBV may be a risk factor for which type of lymphoma as it evades apoptosis- surrounded by a protective eosinophilic inflammatory cells?

Hodgkin

9

Common features of lymphoma

Lymphadenopathy
Hepatic/splenic enlargement
Systemic symptoms

10

Which type of lymphoma is associated with follicles?

Non-Hodkin lymphoma

11

Differential clinical features of non hodkin lymphoma

Extranodal more common
Paraproteinaemia

12

Malignant disorder of the plasma cells

Myeloma

13

Multiple myeloma is defined as what % excess plasma cells in the bone marrow?

10%

14

3 characteristics of multiple myeloma

Excess plasma cells in the bone marrow (10%)
Bone changes-pain/pathological features
Monoclonal paraprotein in serum and/or urine (Mainly IgG, also IgA)

15

How do you identify the monoclonal paraprotein in multiple myeloma?

Immunofixation

16

Describe the effect multiple myeloma has on RBCs, neutrophils and platelets

Anaemia
Neutropenia
Thrombocytopenia

17

Clinical features of multiple myeloma

CRAB
Hypercalcaemia- bone breakdown
Renal insufficiency- deposition of paraprotein
Anaemia
Bone pain

18

Why is infection common in multiple myeloma?

Lack of normal immunoglobulins and neutropenia

19

Describe the pattern of advancement in 3 plasma cell disorders

MGUS>Myeloma>plasma cell leukaemia

20

What does MGUS stand for?

Monoclonal gammopathy of unknown significance

21

Lab findings of MGUS

Low serum levels of paraprotein, and no decrease in normal immunoglobulins.

22

a protein found in the blood only as a result of cancer or other disease.

Paraprotein

23

Aggressive disorder sometimes a development of myeloma, that is characterised by large numbers of plasma cells circulating in peripheral blood. Poor prognosis.

Plasma cell leukaemia