Flashcards in Lymphoma and Myeloma Deck (23)
4 chronic causes of lymphadenopathy that affect the lymphoid lineage
Chronic lymphocytic leukaemia
Non Hodgkin Lymphoma
Enlarged lymph nodes
3 common causes of lymphadenopathy
Autoimmune disease - SLE, HIV
Clonal neoplastic proliferation of lymphoid cells. Arise in the lymph nodes or lymphoid tissue
2 types of lymphomas
Reed sternberge cells are associated with which type of lymphoma?
Males are more commonly affected than females in which type of lymphoma
Hodgkin (the man, non-hodgkin the woman)
EBV may be a risk factor for which type of lymphoma as it evades apoptosis- surrounded by a protective eosinophilic inflammatory cells?
Common features of lymphoma
Which type of lymphoma is associated with follicles?
Differential clinical features of non hodkin lymphoma
Extranodal more common
Malignant disorder of the plasma cells
Multiple myeloma is defined as what % excess plasma cells in the bone marrow?
3 characteristics of multiple myeloma
Excess plasma cells in the bone marrow (10%)
Bone changes-pain/pathological features
Monoclonal paraprotein in serum and/or urine (Mainly IgG, also IgA)
How do you identify the monoclonal paraprotein in multiple myeloma?
Describe the effect multiple myeloma has on RBCs, neutrophils and platelets
Clinical features of multiple myeloma
Hypercalcaemia- bone breakdown
Renal insufficiency- deposition of paraprotein
Why is infection common in multiple myeloma?
Lack of normal immunoglobulins and neutropenia
Describe the pattern of advancement in 3 plasma cell disorders
MGUS>Myeloma>plasma cell leukaemia
What does MGUS stand for?
Monoclonal gammopathy of unknown significance
Lab findings of MGUS
Low serum levels of paraprotein, and no decrease in normal immunoglobulins.
a protein found in the blood only as a result of cancer or other disease.