Infection in the Immunocompromised Host Flashcards Preview

Clinical Pathology > Infection in the Immunocompromised Host > Flashcards

Flashcards in Infection in the Immunocompromised Host Deck (10):
1

Describe a qualitative neutrophilic defect and the likely resulting infection

Chronic granulomatous disease- neutrophils fail to mount a respiratory burst in phagocytosis. Deficient in NADPH oxidase so H2O2 not formed. At risk of Staph Aureus infection

2

What infection is likely to result in a neutropenic patient?

Pseudomonal infections

3

Treatment for neutropenic patients

Broad specturm e.g. antipseudomonal penicillin with or without gentamicin.
2nd line treatment e.g. carbapenem
Granulocyte stimulating factors (GCSF) stimulates immune system.

4

Who might get a T cell deficiency

Rare to be congenital
Acquired- drugs e.g. ciclosporin (immunosuppressant) after transplantation, steroids, HIV

5

How might toxoplasma gondii be spead?

Cat faees or heart transplants-may present with lesion in brain and neurological sing

6

Complement is required to kill what type of bacteria

Encapsulated bacteria:
Strep Pneumo
N. Meningitidis
H, Influenza type B

7

Why might a splenectomy result in immunodeficiency?

The spleen is a source of complement an antibody producing B cells-removes opsonised bacteria from the blood. Causes: trauma, surgical or functional e.g. sickly cell anaemia-many thrombi in spleen that makes it incompetent

8

What infections might be transmitted immediately following transplantation

toxoplasmosis, CMV

9

What type of opportunistic infections during initial immunosuppression following a transplant are likely?

CMV, Aspergillus

10

What type of later opportunistic infections might follow a transplant?

Zoster, Listeria