Flashcards in Infection in the Immunocompromised Host Deck (10):
1
Describe a qualitative neutrophilic defect and the likely resulting infection
Chronic granulomatous disease- neutrophils fail to mount a respiratory burst in phagocytosis. Deficient in NADPH oxidase so H2O2 not formed. At risk of Staph Aureus infection
2
What infection is likely to result in a neutropenic patient?
Pseudomonal infections
3
Treatment for neutropenic patients
Broad specturm e.g. antipseudomonal penicillin with or without gentamicin.
2nd line treatment e.g. carbapenem
Granulocyte stimulating factors (GCSF) stimulates immune system.
4
Who might get a T cell deficiency
Rare to be congenital
Acquired- drugs e.g. ciclosporin (immunosuppressant) after transplantation, steroids, HIV
5
How might toxoplasma gondii be spead?
Cat faees or heart transplants-may present with lesion in brain and neurological sing
6
Complement is required to kill what type of bacteria
Encapsulated bacteria:
Strep Pneumo
N. Meningitidis
H, Influenza type B
7
Why might a splenectomy result in immunodeficiency?
The spleen is a source of complement an antibody producing B cells-removes opsonised bacteria from the blood. Causes: trauma, surgical or functional e.g. sickly cell anaemia-many thrombi in spleen that makes it incompetent
8
What infections might be transmitted immediately following transplantation
toxoplasmosis, CMV
9
What type of opportunistic infections during initial immunosuppression following a transplant are likely?
CMV, Aspergillus
10