Flashcards in Thrombosis and Risk Factors Deck (24):
Risk factors for thrombosis
Virchow's triad- flow, composition or vessel wall
Outline the brief pathology of arterial thrombosis
Atherosclerosis, rupture of atheromatous plaque, endothelial injury, platelet aggregation
Describe the composition of thrombi in venous thrombosis
Pred. fibrin and RBCs, less platelets
Complication of venous thrombosis
Venous thromboembolism (VTE)
Treatment for VTE
Low molecular weight heparin e.g. fondaparinux
Newer anticoagulants e.g:
Xa inhibitors rivaroxaban
IIa inhibitors dabigatran
How does heparin work?
Increases antithrombin activity
Does LMWH predominantly target Xa or IIa?
Does fondaparinoux predominantly target Xa or IIa?
Diagnostic test for VTE
What test is used to measure the breakdown products of fibrin clots- specific to plasmin acting on fibrin
What does the VQ scan pick up in PE?
What are the advantages of novel anticoagulants?
Dose is uniform for post patients and rapid onset
Familial or acquired disorder of the haemostatic mechanism likely to predispose to thrombosis
Protein C def
Protein S def
FV leiden-activated protein C resistance
Too much prothrombin
An example of an acquired thrombophilia
Antiphospholipid syndrome- autoimmune, hypercoagulable state
Clinical features of thrombophilia
Thrombosis of cerebral, axillary, portal and mesenteric veins
Coumarin induced skin necrosis (PC deficiency)
Obstetic complications- fetal wastage- thrombosis of placental circulation
What is the function of protein C
Breaksdown Va and VIIIa
What is the function of protein S
Cofactor for protein C
Describe factor V leiden
Va resistant to protein C