Flashcards in Introduction to Haematology Deck (48)
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1
The physiological development process that gives rise to the cellular components of the blood.
Haemopoiesis
2
What are the 4 forms of self-renewal that a haematopoietic stem cell can undergo
Symetrical self-renewal
Asymetrical self renewal
Lack of self-renewal (2xP)
Lack of self-renewal
3
What type of self renewal increases the stem cell pool?
Symetrical self renewal
4
What type of self renewal maintains the stem cell pool and generates differentiated progeny?
Asymetrical self-renewal
5
What type of self-renewal depletes the stem cell pool and only generates differentiated progeny
Lack of self renewal
6
What are the 2 haematopoietic lineages
Myeloid
Lymphoid
7
At day 27, haemopoiesis starts where?
Aortagonad mesonephros region
8
At day 40, haematopoietic stem cells migrate where?
Foetal liver
9
Life span of erythrocytees
120 days
10
low RBCs
Anaemia
11
high RBCs
Polycythaemia
12
When plasma vol. is low and high conc of RBCs
Relative polycythaemia
13
What are the 2 major groups of leukocytes
Granulocytes (myeloid)
Lymphocytes (lymphoid)
14
Most common WBC
Neutrophils
15
Lifespan of neutrophils
A few hours
16
Increased numbers of neutrophils, when might this happen?
Neutrophilia e.g. infection, inflammation
17
Decreased numbers of neutrophils, when might this happen?
Neutropenia e.g. side effect of a drug
18
A rare WBC, part of the primative immune system
Basophils
19
Describe the differentiation of monocytes
Migrate to tissues and are then identified as macrophages. (histiocytes e.g. kupffer cells in liver, langerhans cells in skin)
20
Increased numbers of monocytes, when might this happen
Monocytosis e.g. TB
21
3 types of lymphocytes
Natural killers
B Lymphocytes
T lymphocytes
22
Innate immune system, large granular lymphocytes that recognise 'non self'
Natural killers
23
Lymphocytes associated with humoral immunity
B cells
24
Lymphocytes associated with cell-mediated immunity
T cells
25
Examples of when you might get lymphocytosis
Glandular fever, chronic lymphocytic leukaemia
26
Examples of when you might get lymphopenia
Post bone marrow transplant
27
Platelets are derived from what cell?
Megakaryocytes
28
Normal Hb concentration
115-175g/L
29
Normal RBC concentration
4-6.5x1012/L
30
