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Clinical Pathology > Disease of the Muscle > Flashcards

Flashcards in Disease of the Muscle Deck (19):
1

5 clinical investigations of muscle disease

Clinical examination (neurological)
Electromyograph
Nerve conduction study
MRI
Serum/blood investigations

2

3 types of muscle disease

Neurogenic muscle disease
Motor end-plate disorder
Primary muscle diseases-myopathies

3

A common disease of the ECM

Duchenne musclular dystrophy

4

What type of inheritence is Duchenne muscular dystrophy?

Sex linked recessive

5

Relentlessly progressive wasting, chair bound by 12 years, hypertrophy of calves

Duchenne muscular dystrophy

6

Pathogenesis of duchenne muscular dystrophy

-

7

Diagnosis of duchenne muscular dystrophy

-

8

A type of muscular dystrophy presenting with weakness of proximal arm and distal leg msucles, early contractures and cardiomyopathy

Emery-dreifuss muscular dystrophy

9

Heterogenous muscular dystrophy

Limb girdle muscular dystrophy

10

3 types of muscular dystrophy

Duchenne
Emery-dreifuss
Limb girdle

11

An internal cytoskeletal protein disease affecting the centre of a muscle fibre which is devoid of normal histochemical reactivity

Central core disease

12

Presentation of nemaline myopathy

Generalised neonatal hypotonia
Respiratory insufficiency
High arched palate
Kyphoscoliosis

13

Abnormal susceptibility to certain inhalational anaesthetic agents- prolonged rise in intracellular calcium ions, rigid contractions and elevation in body temperature

Malignant Hyperthermia

14

Dominantly inherited condition- myotonia and progressive weakness of facial muscles. Onset 20-30yrs. Cardiac conduction defects

Myotonic dystrophy

15

Pathogenesis of myasthenia gravis

Autoimmune disease with antibodies, usually IgG, against the acetylcholine receptor

16

Rare non-metastatic manifestation of malignancy, usually oat-cell carcinoma of the bronchuus

Eaton-Lambert Myasthenic Syndrome

17

An inflammatory myopathy responsible for chronic debilitating disease, and what type of rash?

Dermatomyositis
Scaly rash

18

Cause of acute necrotising myopathy causing rhabdomyolyssis, myoglobinuria and renal failure

Heroin
Ecstasy

19

Motor neuron disease

Progressive- middle to old age
Widespread degeneration of motor neurons
Upper and lower motor neuron signs with wasting associated with spasticity and brisk reflexes