MHC and Transplantation Flashcards Preview

Clinical Pathology > MHC and Transplantation > Flashcards

Flashcards in MHC and Transplantation Deck (7)
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1

Class 1 MHC

Found on all nucleated cells
HLA-A, HLA-B, HLA-C

2

Class 2 MHC

Primarily found on B cells, can be induced on T cells
HLA-DR, DQ, DP

3

Inheritence of MHC

Mendelian-codominant expression

4

Direct recognition

WBCs of donor migrate into the recipeint where they interact directl with recipeint's T cells so they can recognise the HLA for donor cells. Occurs immediately on transplantation

5

Indirect Recognition

Foreign protein is picked up b recipient cells which is broken down by its own immune system, presented to B cells etc.

6

Sensitisation

Any event which elicits an HLA directed immune response e.g. pregnancy, blood transfusion, transplantation

7

Hyperacute regection

Activates clotting cascade and complement

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