MHC and Transplantation Flashcards
1
Q
Class 1 MHC
A
Found on all nucleated cells
HLA-A, HLA-B, HLA-C
2
Q
Class 2 MHC
A
Primarily found on B cells, can be induced on T cells
HLA-DR, DQ, DP
3
Q
Inheritence of MHC
A
Mendelian-codominant expression
4
Q
Direct recognition
A
WBCs of donor migrate into the recipeint where they interact directl with recipeint’s T cells so they can recognise the HLA for donor cells. Occurs immediately on transplantation
5
Q
Indirect Recognition
A
Foreign protein is picked up b recipient cells which is broken down by its own immune system, presented to B cells etc.
6
Q
Sensitisation
A
Any event which elicits an HLA directed immune response e.g. pregnancy, blood transfusion, transplantation
7
Q
Hyperacute regection
A
Activates clotting cascade and complement
