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MS2 - Nervous System > Antidepressants and Mood Stabilizers > Flashcards

Flashcards in Antidepressants and Mood Stabilizers Deck (16):
1

Describe two policies that have reduced suicide by limiting means.

- In England, the most common method of suicide until the 1970s was using the oven. After the country switched to clean gas that cannot be used as a lethal tool, suicide rates dropped by 30%
- In Israel, there had been a high suicide rate among those in the military. Most suicides were on the weekend, so the military prohibited taking guns home over the weekend; this lowered the suicide rate.

2

The time course of ________________ corresponds to response to treatment.

brain-derived neurotrophic factor (BDNF)

3

Placebo studies have shown what effect in the use of SSRIs?

That placebos have a similar response immediately, but that relapse rates are higher in groups on placebos

4

The STAR-D (sp?) study demonstrated what?

That people need to be on antidepressants for 8 - 14 weeks to evaluate efficacy

5

Bupropion is contraindicated in what patients?

Those with bulimia; it can induce seizures in anyone, but it is especially so in those with bulimia.

6

All antidepressants have shown ______________, but ________________.

efficacy in treating depressing; there are no trials comparing efficacy between newer drugs

7

What are the pros and cons of tricyclic antidepressants?

Pros:
- time-tested efficacy
- more effective in severe depression
- blood levels can be monitored

Cons:
- alpha blocking leads to orthostatic hypotension
- antimuscarinic effects
- sexual side effects
- dangerous

8

What drug combination led to Libby Zion's death?

MAO inhibitor and demerol (a pyridine that requires MAO to be metabolized)

9

What are the side effects of SNRIs?

Diastolic hypertension
Withdrawal leads to flu-like symptoms and "electric shock" symptoms in the back of the head
Sweating
Sexual dysfunction

10

What are the three approved treatments for bipolar depression?

Quetiapine
Olanzapine + fluoxetine
Lurasidone

There are zero "large" trials showing positive results in treating bipolar depression.

11

True or false: valproic acid is used as a maintenance treatment.

False. It is only used as an acute treatment for mania.

12

It's thought that SSRIs may promote the expression of _______________, leading to increased neuronal growth (specifically in the hippocampus).

BDNF

13

True or false: more than 50% of people treated with SSRIs will achieve complete remission.

False. Only about 1/3 will.

14

What is the mechanism of mirtazapine?

It blocks 5HT2A, 5HT2C, 5HT3, and alpha-2.

15

Mirtazapine is also helpful in treating _____________.

insomnia

16

What is the best assessment of current research on ketamine treatment for depression?

There is some research, but trials are small and of short duration.

Decks in MS2 - Nervous System Class (111):