Flashcards in Pharmacology of Reward Deck (9):
The brain pathway central to the reinforcing effects of dopaminergic drugs is the _____________.
ventral tegmental area (VTA) to nucleus accumbens
The nucleus accumbens generates ____________.
In general, drugs with shorter half lives and faster onset of action have higher ________________.
Dr. French notes that the amygdala is crucial in what aspect of reward association?
Integrative processing of associations; it does so by receiving input from the cortex and sending projections to the VTA
There are three areas of the prefrontal cortex that connect to the nucleus accumbens: the VMPFC, DLPFC, and OPFC. What is their collective function?
Regulating (OPFC), analyzing (DLPFC), and integrating (VMPFC) impulses with the emotional state – basically, learning to delay/deny gratification
The ____________ induces cravings and sends signals to the VTA and thence nucleus accumbens.
All drugs that induce addiction do so by ________________.
increasing dopamine levels in the nucleus accumbens (some more directly than others)
Other than ketamine, there is another street drug that targets the NMDA receptor: ______________.