CNS Neuropharmacology Flashcards Preview

MS2 - Nervous System > CNS Neuropharmacology > Flashcards

Flashcards in CNS Neuropharmacology Deck (25):
1

The main excitatory neurotransmitter in the CNS is ________, while the main inhibitory neurotransmitter is __________.

glutamate; GABA

2

5HT and indoleamines are other names for __________.

serotonin

3

GABA is formed from glutamate via ____________.

GAD (glutamic acid decarboxylase)

4

How is GABA signalling primarily terminated?

By reuptake into the presynaptic terminal

5

Describe two drugs that prolong/strengthen the GABA signal.

Tiagabine (by inhibiting the reuptake of GABA) and vigabactrin (by inhibiting the degradation)

6

Describe how GABA(A) and GABA(B) work.

They are both inhibitory, but GABA(A) is ionotropic and exerts its effect by opening a chloride channel – which hyperpolarizes the cell. GABA(B) is metabotropic and works by inhibiting adenylyl cyclase – which then decreases calcium conductance and opens potassium channels (both of which hyperpolarize the membrane).

7

Acetylcholine is synthesized by ____________ and degraded by _____________.

choline acetyl transferase (CAT); choline esterase

8

Acetylcholine is pumped into vesicles by the protein ______________.

vesicle-associated transporter (VAT)

9

There are five subtypes of muscarinic acetylcholine channels (M1 - M5). List the mechanisms of each.

M1, M3, M5: Gq stimulation of PLC (GQ is a magazine for men... "the odd man out)
M2, M4: inhibit adenylyl cyclase

10

The rate-limiting enzyme for both dopamine and the catecholamines is ____________.

tyrosine hydroxylase

11

The adrenergic system has four receptors: alpha-1, alpha-2, beta-1, and beta-2. List the mechanism by which each works.

Alpha-1: Gq stimulates PLC
Alpha-2: Gi/o inhibits adenylyl cyclase and opens K channels
Beta-1 and beta-2: stimulates adenylyl cyclase

12

Hierarchical neuron systems are found in delineated pathways such as ____________.

motor and sensory tracts

13

Baclofen is a _________ agonist.

GABA(B)

14

What drug is a GABA(A) antagonist?

Flumazenil

15

Seizures can result from depressed activity of which receptor?

GABA(A) – this is why benzodiazepines are given to those having seizures!

16

What two receptors does lamotrigine block?

Voltage-gated sodium channels and voltage-gated calcium channels

17

Ketamine is an antagonist of the __________ channels.

NMDA

18

Lamotrigine is used to treat __________.

seizures

19

What kind of receptors are NMDA and AMPA?

Ionotropic glutamate receptors

20

Dopamine and norepinephrine only bind to _____________ receptors.

metabotropic

21

Black widow venom works by _____________.

increasing acetylcholine release

22

What is the generic name for Chantix?

Varenicline

23

__________ is an indirect alpha-1 adrenergic agonist.

Pseudophedrine

24

___________ is an alpha-2 adrenergic agonist.

Clonidine

25

Parkinson's results from decreased __________ activity in the nigostriatal pathway.

dopamine

Decks in MS2 - Nervous System Class (111):